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Titolo:
Coronory stenting and platelet glycoprotein IIb/IIIa receptor blockade in acute myocardial infarction
Autore:
Santoro, GM; Bolognese, L;
Indirizzi:
Careggi Hosp, Div Cardiol, I-50134 Florence, Italy Careggi Hosp FlorenceItaly I-50134 Div Cardiol, I-50134 Florence, Italy
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 2, volume: 141, anno: 2001, supplemento:, S
pagine: S26 - S35
SICI:
0002-8703(200102)141:2<S26:CSAPGI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLUMINAL CORONARY ANGIOPLASTY; ANGIOGRAPHIC FOLLOW-UP; THROMBOLYTIC THERAPY; BALLOON ANGIOPLASTY; IMMEDIATE ANGIOPLASTY; CARDIOGENIC-SHOCK; ARTERY STENTS; TRIAL; ABCIXIMAB; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Santoro, GM Careggi Hosp, Div Cardiol, Viale Morgagni 85, I-50134 Florence, Italy Careggi Hosp Viale Morgagni 85 Florence Italy I-50134 , Italy
Citazione:
G.M. Santoro e L. Bolognese, "Coronory stenting and platelet glycoprotein IIb/IIIa receptor blockade in acute myocardial infarction", AM HEART J, 141(2), 2001, pp. S26-S35

Abstract

Background myocardia[ reperfusion in patients with acute myocardial infarction may be successfully achieved with primary angioplasty. However, angioplasty, as a primary reperfusion strategy, has limitations such as early recurrent ischemia and late restenosis and reocclusion. To improve the short- and long-term results of primary angioplasty, the use of adjunct strategieshas been proposed. Methods We reviewed published studies on the effectiveness of primary angioplasty, stenting, and platelet glycoprotein IIb/IIIa receptor blockade andidentified the advantages and disadvantages of these interventions in patients with acute myocardial infarction. Results Recent findings suggest that patients may benefit from stenting ofthe infarct artery and from the use of more potent antiplatelet agents such as platelet glycoprotein IIb/IIIa receptor inhibitors. In randomized trials that compared primary angioplasty versus primary stenting, stent implantation was associated with a lower rate of death, reinfarction, and especially target vessel revascularization. Platelet glycoprotein IIb/IIIa receptorinhibitors prevented acute ischemic complications after primary angioplasty and primary stenting. In addition to maintaining large vessel patency, these drugs may protect the microvasculature after primary stenting, allowingbetter functional recovery of the risk area. Conclusions Coronary artery stenting in acute myocardial infarction reduces the rate of restenosis and the incidence of problems related to recurrentischemia. Platelet glycoprotein IIb/IIIa receptor inhibitors may come to play a key role in association with mechanical reperfusion. However, the cost-effectiveness and long-term clinical outcome of this combined pharmocologic/mechanical intervention require further study before this strategy can be recommended for routine use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:55:04