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Titolo:
Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C
Autore:
Zhang, WJ; Shi, ZX; Wang, BB; Cui, YJ; Guo, JZ; Li, B;
Indirizzi:
China Japan Friendship Inst, Dept Pharmacol, Beijing 100029, Peoples R China China Japan Friendship Inst Beijing Peoples R China 100029 oples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 2, volume: 22, anno: 2001,
pagine: 132 - 136
SICI:
0253-9756(200102)22:2<132:AMEOIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTECTION; MYOCARDIUM; HEART;
Keywords:
allitridum; myocardial ischemia; reperfusion injury; polymyxin B; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Shi, ZX China Japan Friendship Hosp, Dept Heart & Kidney, Beijing 100029, Peoples R China China Japan Friendship Hosp Beijing Peoples R China 100029 China
Citazione:
W.J. Zhang et al., "Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C", ACT PHAR SI, 22(2), 2001, pp. 132-136

Abstract

AIM: To investigate whether allitridum has the effect of pharmacological preconditioning and whether protein kinase C (PKC) plays a role in myocardial protection. METHODS: Thirty-four isolated rabbit hearts which subjected to 30 min of regional myocardial ischemia and 2 h reperfusion, were randomlydivided into 5 groups: control group, ischemic preconditioning (PC) group,allitridum (A) group, polymyxin B (Poly B) group, allitridum + polymyxin B(A + PolyB) group. Infarct size was determined by triphenyltetrazolium staining. RESULTS: Pharmacological preconditioning in hearts with a 5-min allitridum infusion 10 min before the prolonged regional ischemia resulted in significantly smaller infarcts (7% +/- 6% of risk area) than in control hearts (25% +/- 7%, P <0.05). There is no significant difference in infarct size between (A + Poly B) group and control hearts (23% +/- 5% vs 25% +/- 7%, P > 0.05). CONCLUSION: These data indicate that allitridium can precondition rabbit ischemic myocardium and this protection can be effectively blockedby administration of Poly B, an inhibitor of PKC, implying that PKC has animportant role in preconditioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:32:05