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Titolo:
Donepezil in the treatment of progressive supranuclear palsy
Autore:
Fabbrini, G; Barbanti, P; Bonifati, V; Colosimo, C; Gasparini, M; Vanacore, N; Meco, G;
Indirizzi:
Univ La Sapienza, Dept Neurol Sci, Rome, Italy Univ La Sapienza Rome Italy v La Sapienza, Dept Neurol Sci, Rome, Italy
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 2, volume: 103, anno: 2001,
pagine: 123 - 125
SICI:
0001-6314(200102)103:2<123:DITTOP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; SYSTEM;
Keywords:
progressive supranuclear palsy; donepezil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Fabbrini, G Univ La Sapienza, Dept Neurosci, Viale Univ 30, I-00185 Rome, Italy Univ La Sapienza Viale Univ 30 Rome Italy I-00185 Rome, Italy
Citazione:
G. Fabbrini et al., "Donepezil in the treatment of progressive supranuclear palsy", ACT NEUR SC, 103(2), 2001, pp. 123-125

Abstract

Objectives - To evaluate the effect of 3 month therapy with donepezil, a centrally acting cholinesterase inhibitor, on cognitive performances, motor function and daily living activities in progressive supranuclear palsy (PSP). Materials and methods - Six patients with a diagnosis of PSP were evaluated at baseline and after 3 months of treatment with donepezil, 10 mg givenat bedtime. Cognitive functions, motor symptoms and daily activities were evaluated by means of appropriate rating scales. Results - Donepezil was not effective on cognitive dysfunction and did not change ratings of daily living. Parkinsonian symptoms were unaffected by donepezil treatment. Conclusions Cholinergic replacement therapy alone is not likely to improve symptoms in a disorder characterized by a more widespread impairment of monoaminergic systems. Larger studies may be necessary to confirm the lack of effect of donepezil in this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:55:59