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Titolo:
The stimulation of vascular smooth muscle oxidative metabolism by CSF fromsubarachnoid haemorrhage patients increases with fisher and WFNS grades
Autore:
Cadoux-Hudson, TAD; Pyne, GJ; Domingo, Z; Clark, JF;
Indirizzi:
Univ Cincinnati, Med Ctr, Dept Neurol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Neurol, Cincinnati, OH 45267 USA Univ Oxford, Dept Biochem, MRC, Biochem & Clin Magnet Resonance Unit, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU sonance Unit, Oxford OX1 3QU, England Radcliffe Infirm, Dept Neurosurg, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE urosurg, Oxford OX2 6HE, England
Titolo Testata:
ACTA NEUROCHIRURGICA
fascicolo: 1, volume: 143, anno: 2001,
pagine: 65 - 72
SICI:
0001-6268(2001)143:1<65:TSOVSM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-CHAIN PHOSPHORYLATION; CEREBRAL ARTERIAL SPASM; SHORTENING VELOCITY; CANINE MODEL; TIME-COURSE; VASOSPASM; HEMORRHAGE; FORCE; RATS;
Keywords:
force measurement; metabolism; contraction; relaxation; vasospasm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, JF Univ Cincinnati, Med Ctr, Dept Neurol, ML 0536, Cincinnati, OH 45267 USA Univ Cincinnati ML 0536 Cincinnati OH USA 45267 ti, OH 45267 USA
Citazione:
T.A.D. Cadoux-Hudson et al., "The stimulation of vascular smooth muscle oxidative metabolism by CSF fromsubarachnoid haemorrhage patients increases with fisher and WFNS grades", ACT NEUROCH, 143(1), 2001, pp. 65-72

Abstract

The purpose of this paper is to present an in vitro method for examining cerebral vasospasm after subarachnoid haemorrhage (SAH) which correlates to the patients' condition. The Oz consumption of the porcine carotid artery was monitored, using an oxygen electrode, after exposure to cerebrospinal fluid (CSF) from patients who had a SAH. The vessels were exposed to CSF fromSAH patients at a 1 in 30 dilution. Force measurements were carried out using freeze-dried CSF, reconstituted in the organ bath equivalent to undiluted CSP. These observations were then compared to the patients' condition. We divided the patient CSF samples into those that stimulated oxygen consumption above 0.4 muM/min/g dry wt, and those that did not. It was found that there was a correlation between the stimulation of oxygen consumption andthe Fisher grade as well as the World Federation of Neurosurgeons Grading System (WFNS) for the patients. Of the CSF tested. 24 stimulated oxygen consumption above our cut off, and 8 did not (0.84 +/- 0.34, n = 24 compared with the rate of 0.27 +/- 0.1 mu mol/min/g dry wt, respectively; SD n = 8) at 180 minutes. We then examined the Fisher Grades of these two groups, the results were 3.21 +/- 0.88 vs 2.25 +/- 0.83 respectively (SD p less than orequal to 0.01). When examining the WFNS System we found a similar difference between the groups that stimulated respiration and those who did not (WFNS Grades of 2.64 +/- 1.1 vs. 1.43 +/- 0.53; p less than or equal to 0.01). The observed stimulation of oxygen consumption also correlated with tension generation in vitro. The CSF from subarachnoid haemorrhage patients stimulates the oxygen consumption of the porcine carotid artery. This stimulation correlated to the WFNS and Fisher Grades of the patients and can be performed using 1:30 dilution of CSF. We conclude that the metabolic changes that occur in the vesselsduring vasospasm are important parameters for assessing cerebral vasospasm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:55:14