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Titolo:
Dopamine transporter density in young patients with schizophrenia assessedwith [(123)] FP-CIT SPECT
Autore:
Lavalaye, J; Linszen, DH; Booij, J; Dingemans, PMAJ; Reneman, L; Habraken, BAJ; Gersons, BPR; van Royen, EA;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 BC Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 BC C Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 BC Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 BC C Amsterdam, Netherlands Grad Sch Neurosci, Amsterdam, Netherlands Grad Sch Neurosci Amsterdam Netherlands eurosci, Amsterdam, Netherlands
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 47, anno: 2001,
pagine: 59 - 67
SICI:
0920-9964(20010115)47:1<59:DTDIYP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PARKINSONS-DISEASE; DECARBOXYLASE ACTIVITY; GENDER DIFFERENCES; BINDING-SITES; D2 RECEPTORS; SCALE; BRAIN; STRIATUM; DEFICIT;
Keywords:
antipsychotic medication; dopamine transporter; gender; schizophrenia; single photon emission computed tomography; (SPECT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lavalaye, J Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Tafelbergweg 25, NL-1105 BC Amsterdam, Netherlands Univ Amsterdam Tafelbergweg 25 AmsterdamNetherlands NL-1105 BC
Citazione:
J. Lavalaye et al., "Dopamine transporter density in young patients with schizophrenia assessedwith [(123)] FP-CIT SPECT", SCHIZOPHR R, 47(1), 2001, pp. 59-67

Abstract

Disturbances in the dopamine (DA) system are thought to play a major role in schizophrenia. Amphetamine-induced release of endogenous DA is shown to be enhanced in schizophrenia, as is striatal [F-18]FDOPA uptake in the striatum. It is not clear if the density of DA neurons is altered in schizophrenia. By studying the DA transporter with [I-123]FP-CIT single photon emission computed tomography (SPECT), the density of nigrostriatal dopaminergic cells can be studied. Using [I-123]FP-CIT SPECT, DA transporter density in the striatum was studied in 36 young patients with schizophrenia, Ten patients were antipsychotic (AP)-naive, 15 were treated with olanzapine. eight with risperidone and three were AP-free. A control group of 10 age-matched volunteers was included. Striatal [I-123]FP-CIT binding was not significantly different between AP-naive patients (2.87), patients treated with olanzapine (2.76). patients treated with risperidone (2.76). AP-free patients (7.68) and controls (2.82) (F=0.07. p=0.98). Unexpectedly, striatal [I-123]FP-CIT binding in females was significantly higher than in males (3.29 and 2.70, respectively; t = -2.56, p = 0.014). Concluding, functional changes in the dopaminergic system in schizophreniaare not likely to be reflected in a change in DA transporter density. Moreover. DA transporter density does not seem to be altered by AP medication. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 21/01/20 alle ore 07:23:56