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Titolo:
Lack of association between the T -> C 267 serotonin 5-MT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia
Autore:
Masellis, M; Basile, VS; Meltzer, HY; Lieberman, JA; Sevy, S; Goldman, DA; Hamblin, MW; Macciardi, FM; Kennedy, JL;
Indirizzi:
Univ Toronto, Ctr Addict & Mental Hlth, Clarke Div, Neurogenet Sect, Toronto, ON M5T 1R8, Canada Univ Toronto Toronto ON Canada M5T 1R8 Sect, Toronto, ON M5T 1R8, Canada Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA a, Dept Psychiat, Chapel Hill, NC USA Bronx Vet Adm Med Ctr, Dept Vet Affairs, New York, NY USA Bronx Vet Adm Med Ctr New York NY USA Dept Vet Affairs, New York, NY USA NIAAA, Neurogenet Lab, NIH, Rockville, MD 20852 USA NIAAA Rockville MD USA 20852 Neurogenet Lab, NIH, Rockville, MD 20852 USA Univ Washington, VA Puget Sound Hlth Care Syst, GRECC, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 e Syst, GRECC, Seattle, WA 98195 USA Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t & Behav Sci, Seattle, WA 98195 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 47, anno: 2001,
pagine: 49 - 58
SICI:
0920-9964(20010115)47:1<49:LOABTT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; 5-HT2A RECEPTOR; CLINICAL-RESPONSE; TOURETTES-SYNDROME; ALLELIC VARIATION; NO EVIDENCE; RFLP; DISORDERS; EXCLUSION; 8-OH-DPAT;
Keywords:
clozapine response; pharmacogenetic; polymorphism; serotonin receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kennedy, JL Univ Toronto, Ctr Addict & Mental Hlth, Clarke Div, NeurogenetSect, 100 Coll St, Toronto, ON M5T 1R8, Canada Univ Toronto 100 Coll St Toronto ON Canada M5T 1R8 1R8, Canada
Citazione:
M. Masellis et al., "Lack of association between the T -> C 267 serotonin 5-MT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia", SCHIZOPHR R, 47(1), 2001, pp. 49-58

Abstract

The affinity of clozapine for 5-HT2A, 5-HT2C, 5-HT6, 5-HT7, and 5-HT1A receptors has been suggested to contribute to various aspects of its complex clinical actions. This study examined the hypothesis that genetic variation in 5-HT1A, 5-HT6, and 5-HT7 receptor genes is involved in the variability observed in response to clozapine. We employed a pharmacogenetic approach ina group (n=185) of schizophrenia patients that have been clinically well characterized for clozapine response. Polymorphisms in the 5-HT6 (HTR6), 5-MT1A (HTR6) and 5-HT7 (HTR7) receptor genes were genotyped. No evidence for either an allelic or genotypic association of the T-->C 267 HTR6 polymorphism with response to clozapine was found in our sample (allele: chi (2)=0.06, 1 df, P=0.80; genotype: chi (2)=1.21. 2 df, P=0.55), The pro161eu HTR1A polymorphism was not observed in our sample: all individuals genotyped were pro/pro 16 homozygotes, With respect to the pro279leu HTR7 polymorphism, one Caucasian male responder to clozapine was observed to be heterozygous (pro/leu 279 genotype), This individual was clinically similar to the other clozapine responders. Overall, our findings do not support a role for the T-->C 267 polymorphism of the 5-HT6 receptor gene in response to clozapine, although replication is required to confirm this finding. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:48:02