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Titolo:
Elevated dopamine receptor-coupled G(s) protein measures in mononuclear leukocytes of patients with schizophrenia
Autore:
Avissar, S; Barki-Harrington, L; Nechamkin, Y; Roitman, G; Schreiber, G;
Indirizzi:
Ben Gurion Univ Negev, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Ben Gurion Univ Negev, Dept Psychiat, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 47, anno: 2001,
pagine: 37 - 47
SICI:
0920-9964(20010115)47:1<37:EDRGPM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; BIPOLAR AFFECTIVE-DISORDER; GUANINE-NUCLEOTIDE BINDING; BETA-ADRENERGIC-RECEPTOR; ADENYLATE-CYCLASE; GTP-BINDING; SIGNAL-TRANSDUCTION; PARKINSONS-DISEASE; ALPHA-SUBUNIT; GS PROTEIN;
Keywords:
beta-adrenergic; dopamine; G protein; muscarinic; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Avissar, S Ben Gurion Univ Negev, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 heva, Israel
Citazione:
S. Avissar et al., "Elevated dopamine receptor-coupled G(s) protein measures in mononuclear leukocytes of patients with schizophrenia", SCHIZOPHR R, 47(1), 2001, pp. 37-47

Abstract

Heterotrimeric G proteins play a pivotal role in post-receptor informationtransduction and were previously implicated in the pathophysiology and treatment of mood disorders. Changes previously detected in G protein levels in post-mortem brain of patients with schizophrenia could reflect effects ofantipsychotic medication. The present study aims at quantitatively and functionally evaluating receptor-coupled G proteins in mononuclear leukocytes obtained from 23 untreated patients with schizophrenia and 30 healthy subjects in an attempt to unravel a pattern of G protein measures in schizophrenia distinctive from patterns previously obtained in mood disorders. Dopamine-enhanced guanine nucleotide binding capacity to G(s) protein through D-1/D-5 receptor in mononuclear leukocytes of untreated patients with schizophrenia was significantly increased in comparison with healthy subjects, and positively correlated with both the total PANSS score and the positive subscale. beta -Adrenergic and muscarinic receptor-coupled G protein functions. as well as G(s)alpha, G(i)alpha and G beta immunoreactivities, were similarto healthy subjects. These findings, distinctive for schizophrenia, unrelated to drug treatment, and differential from previous findings in mania anddepression, may potentially help to differentially diagnose, after the first psychotic episode. between the major psychoses: schizophrenia and manic-depressive illness. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:47:49