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Titolo:
Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients
Autore:
Theodoropoulou, S; Spanakos, G; Baxevanis, CN; Economou, M; Gritzapis, AD; Papamichail, MP; Stefanis, CN;
Indirizzi:
Univ Athens, Mental Hlth Res Inst, Athens 11528, Greece Univ Athens Athens Greece 11528 ntal Hlth Res Inst, Athens 11528, Greece Evangelismos Gen Hosp, Dept Psychiat, Athens, Greece Evangelismos Gen Hosp Athens Greece Hosp, Dept Psychiat, Athens, Greece St Savas Anticanc Hosp, Canc Immunol Immunotherapy Ctr, Athens, Greece St Savas Anticanc Hosp Athens Greece Immunotherapy Ctr, Athens, Greece
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 47, anno: 2001,
pagine: 13 - 25
SICI:
0920-9964(20010115)47:1<13:CSLAML>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE INTERLEUKIN-2 RECEPTORS; MULTIPLE-SCLEROSIS; CEREBROSPINAL-FLUID; PROTHYMOSIN-ALPHA; PLASMA-LEVELS; CSF LEVELS; EXPRESSION; AUTOIMMUNITY; MONOCYTES; DISEASE;
Keywords:
autologous mixed lymphocyte reaction (AMLR); antipsychotic drug; cytokine; schizophrenia; surface marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Stefanis, CN Univ Athens, Mental Hlth Res Inst, 72-74 Vas Sophias Ave, Athens 11528, Greece Univ Athens 72-74 Vas Sophias Ave Athens Greece 11528 Greece
Citazione:
S. Theodoropoulou et al., "Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients", SCHIZOPHR R, 47(1), 2001, pp. 13-25

Abstract

A number of immunological parameters were studied in 82 DSM-III-R diagnosed schizophrenic patients (53 first drug-naive and 29 medicated chronic patients) as well as 67 healthy blood donors. The serum levels of interleukin-2(IL-2), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) were measured and correlated with cellular immunity, as assessed by the autologous mixed lymphocyte reaction (AMLR). T lymphocyte subsets were also examined. The above immune parameters were reassessed in a subgroupof ii first-episode, drug-naive patients 1 month after neuroleptic medication. IL-2 serum levels were significantly lower, and IL-1 beta and TNF-alpha were significantly higher in schizophrenic patients compared with healthydonors (P<0.001), no significant difference was observed between the two patient groups (medicated and not medicated). Abnormal cytokine serum levelswere associated with decreased AMLR responses in vitro. Increased percentages of activated CD4+ and CD16+ natural killer cells, as well as cells expressing ICAM-1 adhesion molecules and IL-2 specific receptors, were detectedin the patients. Immunophenotype studies revealed a higher percentage of cells expressing IL-2 receptors in medicated chronic schizophrenic patients compared with drug-naive patients. The abnormal cytokine production in vivo. along with the low AMLR responses in vitro. and the high percentage of activated CD4+ lymphocytes presented in this study suggest alterations in theimmune system of schizophrenic patients (medicated or not medicated) consistent with immune activation. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 09/07/20 alle ore 13:44:37