Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Schizophrenia and HLA: a review
Autore:
Wright, P; Nimgaonkar, VL; Donaldson, PT; Murray, RM;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Univ London Kings Coll Hosp, London SE5 8AF, England Univ London Kings Coll Hosp London England SE5 8AF ndon SE5 8AF, England Univ Pittsburgh, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 & Clin, Pittsburgh, PA 15213 USA Univ Newcastle Upon Tyne, Sch Clin Med Sci, Liver Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle UponTyne Tyne & Wear England NE2 4HH
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 47, anno: 2001,
pagine: 1 - 12
SICI:
0920-9964(20010115)47:1<1:SAHAR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II; CHROMOSOME 6P21.3; GENE LOCUS; DRB1 GENE; JAPANESE SCHIZOPHRENICS; ANKYLOSING-SPONDYLITIS; RHEUMATOID-ARTHRITIS; MYASTHENIA-GRAVIS; ANTIGENS; ASSOCIATION;
Keywords:
autoimmunity; genetic association; HLA; review; schizophrenia; schizophrenia locus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Wright, P Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF F, England
Citazione:
P. Wright et al., "Schizophrenia and HLA: a review", SCHIZOPHR R, 47(1), 2001, pp. 1-12

Abstract

A number of reports of genetic association of human leucocyte antigens (HLA) and alleles with schizophrenia have recently been published. A schizophrenia locus on chromosome 6p near the HLA region has also been reported, on the basis of linkage studies. We have therefore reviewed the investigationsof association of HLA with schizophrenia published from 1974 to date, and have also briefly reviewed the chromosome 6p linkage studies. Two or more groups of investigators have reported association of each of the following HLA antigens or alleles with schizophrenia - A9 or its A24 subspecificity. A28, A10, DRB1*01 and DRw6. However, these results may represent Type I errors caused by small sample size, inappropriate diagnostic, laboratory and/orstatistical methodology, and/or incorrectly chosen comparison subjects. Hypothesis-driven negative associations of DRB1*04 and DQB1*0602 with schizophrenia have also been reported. Taken together, however, HLA association investigations provide only weak evidence for the existence of either resistance or susceptibility loci for schizophrenia close to the HLA region at the6p21.3 band and, indeed, recently reported investigations that controlled for most of these confounders found no evidence of association. Linkage studies suggest that a susceptibility locus may exist and that it may be within the HLA region, but again the evidence is far from conclusive. Further HLA association investigations should employ operational diagnostic criteria,comparison subjects screened for illness and HLA genotyping, and should include both association studies of candidate alleles and transmission disequilibrium and haplotype relative risk studies. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:48:06