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Titolo:
Gender differences in poor outcome patients with lifelong schizophrenia
Autore:
Moriarty, PJ; Lieber, D; Bennett, A; White, L; Parrella, M; Harvey, PD; Davis, KL;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA CUNY Mt SinaiSch Med New York NY USA 10029 chiat, New York, NY 10029 USA
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 1, volume: 27, anno: 2001,
pagine: 103 - 113
SICI:
0586-7614(2001)27:1<103:GDIPOP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINI-MENTAL STATE; COGNITIVE IMPAIRMENT; PSYCHIATRIC-PATIENTS; AFFECTIVE-DISORDERS; ALZHEIMERS-DISEASE; GERIATRIC-PATIENTS; RATING-SCALE; ONSET; SYMPTOMS; AGE;
Keywords:
schizophrenia; aging; gender; cognition; negative symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Harvey, PD CUNY Mt Sinai Sch Med, Dept Psychiat, Box 1229, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1229 New York NY USA 10029 10029 USA
Citazione:
P.J. Moriarty et al., "Gender differences in poor outcome patients with lifelong schizophrenia", SCHIZO BULL, 27(1), 2001, pp. 103-113

Abstract

Gender effects have been reported quite consistently in schizophrenia, with male patients having an earlier age of onset, poorer functional outcome, greater negative symptoms and cognitive impairment, and less severe positive symptoms. Because age of onset, cognitive impairments, and negative symptoms are all correlated,vith poorer functional status, it is not clear if previously reported gender differences in symptoms are just recapturing gender differences in functional outcome. In this study, 205 geriatric patients with lifelong poor-outcome schizophrenia (43% male) were examined for the severity of schizophrenic symptoms, cognitive impairments, and specific deficits in adaptive skills, as well as for demographic differences such as ageat first psychiatric admission, premorbid education, and current treatmentstatus. Previously reported gender differences were replicated in these patients with a uniformly poor functional outcome, with male patients having more severe negative symptoms and an earlier age of first psychiatric admission. No differences in cognitive functioning or specific functional deficits were found, however. These findings suggest that negative symptom severity is greater in male patients regardless of functional outcome and that the association of cognitive deficits with gender may be found only in patients with better functional outcome. The study of gender-related differences in brain structure or function and their interaction with overall course ofillness might help understand these differences in symptom presentation.

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Documento generato il 25/01/20 alle ore 10:19:45