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Titolo:
Pharmacoepidemiology and gastroenterology: a close couple
Autore:
Leufkens, HG;
Indirizzi:
Utrecht Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3508 TB Utrecht, Netherlands Utrecht Inst Pharmaceut Sci Utrecht Netherlands NL-3508 TB , Netherlands
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
, volume: 35, anno: 2000, supplemento:, 232
pagine: 105 - 108
SICI:
0036-5521(2000)35:<105:PAGACC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMARKETING SURVEILLANCE; DRUG; SAFETY; RISK;
Keywords:
drug safety; gastropathy; NSAID; pharmacoepidemiology; postmarketing surveillance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Leufkens, HG Utrecht Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, POB80082, NL-3508 TB Utrecht, Netherlands Utrecht Inst PharmaceutSci POB 80082 Utrecht Netherlands NL-3508 TB
Citazione:
H.G. Leufkens, "Pharmacoepidemiology and gastroenterology: a close couple", SC J GASTR, 35, 2000, pp. 105-108

Abstract

The discipline of pharmacoepidemiology has always been strongly linked with the problem of gastrointestinal injury caused by non-steroidal anti-inflammatory drugs, and has led to a close liaison between gastroenterology and pharmacoepidemiology. Aim: This paper discusses three important areas of pharmacoepidemiological interest relevant to gastroenterologists: confoundingby indication and channeling bias, drug exposure patterns, and postmarketing surveillance studies, (i) Drug prescribing is associated with a patientsprognosis and disease status, called indication for treatment. These patient disease characteristics can drive drug channeling in risk populations and create confounded drug-effect associations. (ii) Drug exposure is the result of the 'natural' experiment of pharmacotherapy over time. Reliable information on the time-sequence of events in relation to drug exposure is required to evaluate both beneficial and adverse effects of drug therapy. (iii)Postmarketing surveillance studies provide intensive learning about drug effects when large spectra of patients with various medical backgrounds, prognoses, co-morbidity, and the like, are exposed to the drug. Information ondrug use and patient outcomes in 'real life' populations is necessary to bridge normal practice experiments with randomized clinical trials.

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Documento generato il 19/01/20 alle ore 20:32:03