Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma
Autore:
Stratton, RJ; Wilson, H; Black, CM;
Indirizzi:
Royal Free Hosp, Dept Rheumatol, London NW3 2QG, England Royal Free Hosp London England NW3 2QG heumatol, London NW3 2QG, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 1, volume: 40, anno: 2001,
pagine: 84 - 88
SICI:
1462-0324(200101)40:1<84:PSOAGP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SYSTEMIC-SCLEROSIS; PATHOGENESIS; GRAFT; ACID; SKIN;
Keywords:
diffuse scleroderma; ATG; MMF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Black, CM Royal Free Hosp, Dept Rheumatol, Pond St, London NW3 2QG, England Royal Free Hosp Pond St London England NW3 2QG NW3 2QG, England
Citazione:
R.J. Stratton et al., "Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma", RHEUMATOLOG, 40(1), 2001, pp. 84-88

Abstract

Objective. To assess the safety and efficacy of anti-thymocyte globulin (ATG) followed by mycophenolate mofetil (MMF) in the treatment of diffuse scleroderma. Methods. A pilot study of 13 patients with recent-onset diffuse scleroderma was carried out. Patients received ATG for 5 days, followed by MMF for 12months. We recorded adverse events, scleroderma skin score, hand contractures, EuroQol score, scleroderma functional assessment, pulmonary function studies, echocardiogram and plasma creatinine concentration. Results. Mean skin score decreased during the study from 28 at baseline to17 after 12 months of MMF (P < 0.01). Hand contractures worsened during the study. Mean measurements of systemic disease remained stable. One patientdied after a scleroderma renal crisis. Five patients developed serum sickness after ATG treatment, but this was controlled by corticosteroid therapy. MMF therapy was well tolerated. Conclusion. ATG and MMF appear safe in scleroderma. The improvement in skin score: and the apparent stability of systemic disease during the study period suggest that controlled studies of these agents are justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:34:59