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Titolo:
HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients
Autore:
Caliz, R; Atsumi, T; Kondeatis, E; Amengual, O; Khamashta, MA; Vaughan, RW; Lanchbury, JS; Hughes, GRV;
Indirizzi:
St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Res Unit, London SE1 7EH, England Guys Hosp, Tissue Typing Dept, London SE1 9RT, England Guys Hosp London England SE1 9RT ue Typing Dept, London SE1 9RT, England UMDS, Mol Immunogenet Div Med, London, England UMDS London EnglandUMDS, Mol Immunogenet Div Med, London, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 1, volume: 40, anno: 2001,
pagine: 31 - 36
SICI:
1462-0324(200101)40:1<31:HCIGPI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; PRIMERS PCR-SSP; ANTICARDIOLIPIN ANTIBODIES; ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES; RECOGNIZE BETA(2)-GLYCOPROTEIN-I; PEPTIDE BINDING; BETA-2-GLYCOPROTEIN-I; AUTOANTIBODIES; ASSOCIATION; ALLELES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Khamashta, MA St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England St Thomas Hosp London England SE1 7EH don SE1 7EH, England
Citazione:
R. Caliz et al., "HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients", RHEUMATOLOG, 40(1), 2001, pp. 31-36

Abstract

Objectives. We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS). Methods. HLA DRB1, DQB1 and DQA1 genotypes were determined by the polymerase chain reaction using sequence-specific primers in 83 Caucasoid British patients with APS. The genotype frequencies were compared between subgroups of patients acid 177 healthy controls. Results. DPB1*0604/5/6/7/9-DQA1*0102-DRB1*1302 and DQB1*0303-DQA1*0201-DRB1*0701 haplotypes showed significantly positive correlations with APS [P = 0.0087 and P = 0.0012, respectively]. The association of the former was enhanced in primary APS patients with anti-beta2-glycoprotein I antibodies (anti-beta 2GPI) [odds ratio 6.2, 95% confidence interval (2.2-17.6). P = 0.0014, corrected P = 0.042]. Conclusions. These alleles and haplotypes might affect anti-beta 2GPI production and APS development in different and heterogeneous fashion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:51:28