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Titolo:
Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task
Autore:
Aultman, JM; Moghaddam, B;
Indirizzi:
Yale Univ, Sch Med, VA Med Ctr 116A22, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 6A22, Dept Psychiat, W Haven, CT 06516 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 153, anno: 2001,
pagine: 353 - 364
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL DELAYED ALTERNATION; SHORT-TERM-MEMORY; NONCOMPETITIVE NMDA ANTAGONIST; MEDIAL PREFRONTAL CORTEX; TO-SAMPLE PERFORMANCE; POSITION TASK; TRANSMITTER RELEASE; DOUBLE DISSOCIATION; RECOGNITION MEMORY; CHOLINERGIC DRUGS;
Keywords:
prefrontal cortex; D1 receptor; schizophrenia; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Moghaddam, B Yale Univ, Sch Med, VA Med Ctr 116A22, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 ychiat, W Haven, CT 06516 USA
Citazione:
J.M. Aultman e B. Moghaddam, "Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task", PSYCHOPHAR, 153(3), 2001, pp. 353-364

Abstract

Rationale: Understanding the mechanistic basis of working memory, the capacity to hold representation "on line," is important for delineating the processes involved in higher cognitive functions and the pathophysiology of thought disorders. Objectives: We compared the contribution of glutamate and dopamine receptor subtypes to temporal aspects of working memory using a modified rodent spatial working memory task that incorporates important elements of clinical working memory tasks. Methods: A discrete paired-trial variable-delay T-maze task was used. Initial characterization studies indicatedthat performance on this task is stable at seconds-long retention intervals, is sensitive to retention interval and proactive interference, and is dependent on the integrity of the medial prefrontal cortex. Results: Consistent with clinical findings, low dose amphetamine (0.25 mg/kg) produced a delay-dependent improvement in performance, while higher doses impaired performance at all retention intervals. D1 receptor blockade produced the predicted dose- and delay-dependent impairment. D2 receptor blockade had no effect. Activation of metabotropic glutamate 2/3 (mGluR2/3) receptors, which in the prefrontal cortex inhibits the slow asynchronous phase of glutamate release, also produced a delay-dependent impairment. Low doses of an AMPA/kainate antagonist had effects similar to the mGluR2/3 agonist. In contrast, NMDA receptor antagonist-induced impairment was memory load-insensitive, resulting in chance-level performance at all retention intervals. Conclusions: These findings suggest that activation of NMDA receptors is necessary for the formation of mnemonic encoding while modulatory components involving slowasynchronous release of glutamate and phasic release of dopamine contribute to the active maintenance of information during the delay period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:22:29