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Titolo:
Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine
Autore:
Wallace, TL; Gudelsky, GA; Vorhees, CV;
Indirizzi:
Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn Cincinnati OH USA 45229 , Cincinnati, OH 45229 USA Univ Cincinnati, Grad Program Neurosci, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA d Program Neurosci, Cincinnati, OH USA Univ Cincinnati, Coll Pharm, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA innati, Coll Pharm, Cincinnati, OH USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 153, anno: 2001,
pagine: 321 - 326
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STEREOTYPED BEHAVIOR; NUCLEUS ACCUMBENS SEPTI; SLEEP-WAKING CYCLE; DOPAMINERGIC INNERVATION; SEROTONERGIC PATHWAYS; STRIATAL DOPAMINE; EVOKED OVERFLOW; RAPHE DORSALIS; TIME-COURSE; BRAIN;
Keywords:
methamphetamine; MDMA; neurotoxicity; locomotor activity; diurnal cycle; nocturnal cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Vorhees, CV Childrens Hosp Res Fdn, Div Dev Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn 3333 Burnet Ave Cincinnati OH USA 45229
Citazione:
T.L. Wallace et al., "Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine", PSYCHOPHAR, 153(3), 2001, pp. 321-326

Abstract

Rationale: The long-term neurochemical effects produced by the repeated administration of methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) are well documented; however, the functional consequences have not been clearly defined. Objective: The present study was designed to investigate whether rats treated with a monoamine-depleting regimen of MA or MDMA exhibit disturbances in locomotor activity during the diurnal and nocturnal cycles. Methods: Rats were treated with the vehicle or a monoamine-depletingregimen of MA or MDMA (10 mg/kg, IP, every 2 h for four injections on a single day). One week after drug treatment, the rats were placed in residential activity chambers and their locomotor activity was monitored for the next 7-day/night cycles. Results: MA-treated rats exhibited depletions of striatal dopamine and serotonin content of approximately 70%, whereas MDMA-treated rats showed depletions of striatal serotonin content of approximately 50%. Rats treated with MA demonstrated a significant reduction in diurnal, but not nocturnal, locomotor activity, whereas MDMA-treated rats exhibited significant reductions in both diurnal and nocturnal locomotor activity. Analysis of the difference in activity between the nocturnal and diurnal cycles revealed that MA-treated animals exhibited a significantly greater changein activity as compared to that observed in vehicle- and MDMA-treated rats. Conclusions: Although it is unknown whether the adaptations in locomotor activity observed in MA- and MDMA-treated rats are due to the loss of dopamine and/or serotonin, these data suggest that the administration of a monoamine-depleting regimen of MA or MDMA results in alterations in light-cycle-dependent locomotor activity.

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Documento generato il 17/01/20 alle ore 20:09:51