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Titolo:
An association study between 5-HTTLPR polymorphism, COMT polymorphism, andTourette's syndrome
Autore:
Cavallini, MC; Di Bella, D; Catalano, M; Bellodi, L;
Indirizzi:
Univ Milan, Sch Med, Dept Neurosci, Ist Sci H San Raffaele, I-20127 Milan,Italy Univ Milan Milan Italy I-20127 t Sci H San Raffaele, I-20127 Milan,Italy
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2-3, volume: 97, anno: 2000,
pagine: 93 - 100
SICI:
0165-1781(200012)97:2-3<93:AASB5P>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; CATECHOL-O-METHYLTRANSFERASE; ATTENTION-DEFICIT HYPERACTIVITY; AUTOSOMAL-DOMINANT TRANSMISSION; SEROTONIN TRANSPORTER GENE; RECEPTOR GENE; REGULATORY REGION; LINKAGE ANALYSIS; GILLES; SUSCEPTIBILITY;
Keywords:
serotonin; catecholamine; association studies; obsessive-compulsive disorder; spectrum disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Cavallini, MC Univ Milan, Sch Med, Dept Neurosci, Ist Sci H San Raffaele, Via L Prinetti29, I-20127 Milan, Italy Univ Milan Via L Prinetti 29 Milan Italy I-20127 lan, Italy
Citazione:
M.C. Cavallini et al., "An association study between 5-HTTLPR polymorphism, COMT polymorphism, andTourette's syndrome", PSYCHIAT R, 97(2-3), 2000, pp. 93-100

Abstract

Several lines of evidence suggest that a genetic component underlies Tourette's syndrome (TS). We investigated both the role of the insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and that of the Val-158-Met substitution in the catechol-O-methyl-transferase (COMT) gene in conferring susceptibility to TS. Fifty-two TS patients were recruited and compared with a control group of 63 healthy subjects. Neither a genotypic nor an allelic association was found; subdividing TS patients according to clinical variables, such as a co-diagnosis of obsessive-compulsive disorder (OCD) and a positive family history for obsessive compulsive disorder or ties, also failed to reveal a significant association. The lack of significance for 5-HTTLPR and COMT polymorphisms in conferring liability to TS does not exclude a role of different functional polymorphisms in genes coding for serotonergic or dopaminergic structures in the etiology of TS. In fact, TS is a complex disorder and these genes most likelyhave only a minor genetic effect in its etiology. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 02/04/20 alle ore 07:37:32