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Titolo:
Interaction of endostatin with integrins implicated in angiogenesis
Autore:
Rehn, M; Veikkola, T; Kukk-Valdre, E; Nakamura, H; Ilmonen, M; Lombardo, CR; Pihlajaniemi, T; Alitalo, K; Vuori, K;
Indirizzi:
Burnham Inst, Ctr Canc Res, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 , Ctr Canc Res, La Jolla, CA 92037 USA Oulu Univ, Dept Biochem Med, FIN-90014 Oulu, Finland Oulu Univ Oulu Finland FIN-90014 pt Biochem Med, FIN-90014 Oulu, Finland Oulu Univ, Collagen Res Unit, Bioctr, FIN-90014 Oulu, Finland Oulu Univ Oulu Finland FIN-90014 s Unit, Bioctr, FIN-90014 Oulu, Finland Univ Helsinki, Haartman Inst, Mol Can Biol Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 3, volume: 98, anno: 2001,
pagine: 1024 - 1029
SICI:
0027-8424(20010130)98:3<1024:IOEWII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELL APOPTOSIS; BASEMENT-MEMBRANE ZONES; ALPHA-V INTEGRINS; FIBRONECTIN RECEPTOR; EXTRACELLULAR-MATRIX; INHIBITOR ENDOSTATIN; SIGNAL-TRANSDUCTION; BLOOD-VESSELS; TUMOR-GROWTH; ZINC-BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Vuori, K Burnham Inst, Ctr Canc Res, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 c Res, La Jolla, CA 92037 USA
Citazione:
M. Rehn et al., "Interaction of endostatin with integrins implicated in angiogenesis", P NAS US, 98(3), 2001, pp. 1024-1029

Abstract

Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with alpha (5)- and alpha (v)-integrins on the surface of human endothelial cells. We further demonstrate that the endostatin-integrin interaction is of functional significance in vitro, as we found that immobilized endostatin supports endothelial cell survival and migration in an integrin-dependent manner. Soluble endostatin in turn inhibits integrin-dependent endothelial cell functions, such as cell migration. Taken together, these results implicate integrins as potential targets for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:38:25