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Titolo:
The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia colidivision cycle
Autore:
Fu, XL; Shih, YL; Zhang, Y; Rothfield, LI;
Indirizzi:
Univ Connecticut, Ctr Hlth, Dept Microbiol, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 robiol, Farmington, CT 06030 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 3, volume: 98, anno: 2001,
pagine: 980 - 985
SICI:
0027-8424(20010130)98:3<980:TMRRFP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TO-POLE OSCILLATION; INHIBITOR MINC; RAPID POLE; PROTEIN; FTSZ; MUTANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Rothfield, LI Univ Connecticut, Ctr Hlth, Dept Microbiol, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 gton, CT 06030 USA
Citazione:
X.L. Fu et al., "The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia colidivision cycle", P NAS US, 98(3), 2001, pp. 980-985

Abstract

Placement of the division site at midcell in Escherichia coli requires theMinE protein. MinE acts by imparting topological specificity to the MinCD division inhibitor, preventing the inhibitor from acting at the midcell site while permitting it to block division at other unwanted sites along the length of the cell. It was previously shown that MinE assembled into a ring structure that appeared to be localized near midcell, apparently explainingthe ability of MinE to specifically counteract MinCD at midcell. We reporthere that the MinE ring is not fixed in position near midcell but is a dynamic structure that undergoes a repetitive cycle of movement first to one cell pole and then to the opposite pole. Taken together with studies of the dynamic behavior of the MinD protein, the results suggest that the topological specificity of division site placement may not involve a localized action of MinE to counteract the MinCD division inhibitor at midcell but ratherthe ability of MinE to move the division inhibitor away from midcell and to the cell poles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:17:19