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Titolo:
Lewis/Fischer rat strain differences in endocrine and behavioural responses to environmental challenge
Autore:
Stohr, T; Szuran, T; Welzl, H; Pliska, V; Feldon, J; Pryce, CR;
Indirizzi:
Swiss Fed Inst Technol, Lab Behav Neurobiol, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland Swiss Fed Inst Technol, Dept Anim Sci, CH-8092 Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland CH-8092 92 Zurich, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 67, anno: 2000,
pagine: 809 - 819
SICI:
0091-3057(200012)67:4<809:LRSDIE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; SCHEDULE-INDUCED-POLYDIPSIA; ELEVATED PLUS-MAZE; ANXIETY-RELATED BEHAVIORS; ACOUSTIC STARTLE REFLEX; ADRENAL HPA AXIS; LEWIS RATS; EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; SPRAGUE-DAWLEY;
Keywords:
Lewis rat; Fischer rat; stressor; HPA axis; emotional behaviour; CRF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Pryce, CR Swiss Fed Inst Technol, Lab Behav Neurobiol, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
T. Stohr et al., "Lewis/Fischer rat strain differences in endocrine and behavioural responses to environmental challenge", PHARM BIO B, 67(4), 2000, pp. 809-819

Abstract

The Lewis (LEW) and Fischer (F344) rat strains provide a comparative modelof hypothalamic - pituitary - adrenal (HPA) function in which LEW is relatively hypoactive at homeostasis and hyporeactive to environmental challenge. The present study describes a comparison of LEW and F344 rats, males and females, in terms of their corticosterone (CORT) or behavioural responses to a range of behavioural tasks, where each of the tasks used contains a stressor component and has been demonstrated to be sensitive to corticotropin releasing factor (CRF) and/or CORT manipulation: acoustic startle response (ASR), elevated plus maze, schedule-induced polydipsia, and fear-conditioned suppression of drinking. Our aim was to determine to what extent the LEW trait of HPA axis hyporesponsiveness is associated with strain differences in behavioural responsiveness to environmental challenge. As expected, young (2 - 3 months)- mature (5-10 months) LEW males and females exhibited a lesser CORT response to restraint and novel confinement than did F344 males and females, although in old adulthood (18 months) the CORT stress response was equable in LEW/F344 males and actually higher in LEW than in F344 females. In young-mature adults, the ASR was greater in LEW males than in the other groups; all groups spent a low proportion of time on the open arms of the elevated plus maze; polydipsia was greater in F344 females than in the other groups; and fear-conditioned suppression of drinking was greater in F344 males and females than in LEW males and females. Therefore, relative hyporeactivity of the HPA axis in LEW rats is clearly not associated with uniform behavioural hyporeactivity, including CRF-dependent behaviours. Rather,this study suggests further evidence that environmental reactivity reflects a number of distinct emotional states and underlying neural circuits. (C)2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 17/01/20 alle ore 20:08:09