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Titolo:
Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: acomparison with effects of MAO A inhibitor clorgyline
Autore:
Popova, NK; Vishnivetskaya, GB; Ivanova, EA; Skrinskaya, JA; Seif, I;
Indirizzi:
Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090 90, Russia Russian Acad Sci Novosibirsk Russia 630090 90 osibirsk 630090 90, Russia Inst Curie, CNRS, F-91405 Orsay, France Inst Curie Orsay France F-91405Inst Curie, CNRS, F-91405 Orsay, France
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 67, anno: 2000,
pagine: 719 - 727
SICI:
0091-3057(200012)67:4<719:ABAATI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-A; PREPULSE INHIBITION; RATS; GENE; NOREPINEPHRINE; ASSOCIATION; MODULATION; SEROTONIN; DOPAMINE;
Keywords:
MAO A-knockout; behavior; startle reflex; exploratory activity; alcohol tolerance; clorgyline; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Popova, NK Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Lavrentieva 10, Novosibirsk 630090 90, Russia Russian Acad Sci Lavrentieva 10 Novosibirsk Russia 630090 90 a
Citazione:
N.K. Popova et al., "Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: acomparison with effects of MAO A inhibitor clorgyline", PHARM BIO B, 67(4), 2000, pp. 719-727

Abstract

The influence of deficiency of monoamine oxidase A (MAO A) gene and the lack of enzyme MAO A on the behavior of transgenic mouse strain (Tg8) was studied. It was shown that MAO A-lacking mice differed from mice of the wild-type strain C3H/HeJ (C3H) by an attenuated acoustic startle response, prepulse inhibition (PPI) was unchanged. In Tg 8 mice, the exploratory nose-poking in the holeboard test as well as exploratory line crossing in the "light-dark" test were decreased. No effect of MAO A deficiency on locomotor activity was found. No alcohol preference or difference between Tg8 and C3H in ethanol consumption in the free-choice test has been found, although an increase in alcohol tolerance has been demonstrated. Ethanol-induced (0.3 g/100g ip) sleep latency was longer, duration of sleep was shorter and ethanol hypothermia was reduced in MAO A-lacking mice. Comparison of effects of MAOA knockout with those of irreversible MAO A inhibitor clorgyline (5 and 10mg/kg ip) on C3H mice showed a similar reducing effect on ethanol-induced sleep, but potentiated ethanol-induced hypothermia. Clorgyline administration provoked a tendency to decrease of exploratory activity in the nose-poking test and decreased the frequency of exploratory rearings in the light-dark test. Clorgyline (5 and 10 mg/kg) did not affect the acoustic startle response, but a dose of 5 mg/kg diminished PPI, Therefore, Tg8 mice exhibiteda decreased startle response and exploratory activity and an increased tolerance to ethanol. A similar increase in tolerance to ethanol-induced sleepand a tendency to decrease exploratory behavior were displayed by clorgyline. Other effects on behavior were different, suggesting the influence of long-lasting action of MAO A knockout and the involvement of a compensatory mechanism in Tg8 mice. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 21/10/20 alle ore 10:47:13