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Titolo:
Selective breeding of 5-HT1A receptor-mediated responses: application to emotion and receptor action
Autore:
Knapp, DJ; Sim-Selley, LJ; Breese, GR; Overstreet, DH;
Indirizzi:
Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Inst Drug & Alcohol Studies, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 67, anno: 2000,
pagine: 701 - 708
SICI:
0091-3057(200012)67:4<701:SBO5RR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED G-PROTEINS; RAT-BRAIN; FUNCTIONAL INTERACTION; BEHAVIORAL EVIDENCE; SOCIAL-INTERACTION; PREFRONTAL CORTEX; 5-HT(1A) RECEPTOR; ETHANOL INTAKE; ANXIETY; AGONIST;
Keywords:
8-OH-DPAT; DPO; 5-HT1A; 5-HT2; HDS; LDS; hypothermia; 5-HT receptors; selective breeding; agonist-stimulated [S-35]GTP gamma S autoradiography; review; behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Knapp, DJ Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, CB 7178, Chapel Hill, NC 27599 USA Univ N Carolina CB 7178 Chapel Hill NC USA 27599 l, NC 27599 USA
Citazione:
D.J. Knapp et al., "Selective breeding of 5-HT1A receptor-mediated responses: application to emotion and receptor action", PHARM BIO B, 67(4), 2000, pp. 701-708

Abstract

Rat lines that were selectively bred for high (high DPAT-sensitive, HDS) or low (low DPAT-sensitive, LDS) hypothermic responses to the specific 5-HT1A receptor agonist, 8-hydroxy-di-n-propylaminotetralin (8-OH-DPAT), differ in receptor binding and certain behaviors related to anxiety and depression. After reviewing this literature, the present communication summarizes newexperiments designed to clarify and extend the nature of the pharmacological and biochemical differences between the lines. A challenge with the 5 HT2 receptor agonist, DOI, produced similar degrees of head shakes and skin crawls in the HDS and LDS rats, suggesting similar sensitivity of 5-HT2A and5-HT2C receptors. In contrast, DOI-induced flat body posture (FBP), which has been linked to 5-HT1A receptor stimulation, was observed more readily in the HDS rats. The HDS and LDS rats exhibited similar degrees of increase in 8-OH-DPAT-stimulated [S-35]GTP gammaS binding in several brain regions. This result suggests that the dramatic differences in hypothermia in HDS and LDS rats cannot be related to 5-HT1A receptor-mediated action on G proteins. Overall, these findings indicate that the selective breeding for 5-HT1A-mediated hypothermia has been fairly selective, and that differences in emotionally relevant behaviors between these two rat lines can strongly be associated with an unidentified component of the 5-HT1A receptor signaling pathway. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 27/09/20 alle ore 22:32:17