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Titolo:
Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice
Autore:
Cunningham, CL; Howard, MA; Gill, SJ; Rubinstein, M; Low, MJ; Grandy, DK;
Indirizzi:
Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 urosci, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 v Biol, Portland, OR 97201 USA Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ, Portland Alcohol Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 es Ctr, Portland, OR 97201 USA CONICET, Inst Invest Ingn Genet & Biol Mol, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos Aires DF Argentina RA-1033 033 Buenos Aires, DF, Argentina Univ Buenos Aires, Dept Biol, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 67, anno: 2000,
pagine: 693 - 699
SICI:
0091-3057(200012)67:4<693:EPPIRI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT INBRED MICE; LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; TASTE-AVERSION; SENSITIVITY; REWARD; HALOPERIDOL; HYPOTHESIS; NALOXONE; RELEASE;
Keywords:
ethanol; conditioned place preference; locomotor activity; dopamine D2 receptor; knockout mice; C57BL/6xDBA/2 F2 hybrid mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cunningham, CL Oregon Hlth Sci Univ, Dept Behav Neurosci, L470,3181 SW SamJackson Pk Rd,Portland, OR 97201 USA Oregon Hlth Sci Univ L470,3181 SW SamJackson Pk Rd Portland OR USA 97201
Citazione:
C.L. Cunningham et al., "Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice", PHARM BIO B, 67(4), 2000, pp. 693-699

Abstract

Pharmacological blockade studies have supported a role of the dopamine system in ethanol reward for many years, but receptor subtype specificity has been difficult to establish. Recently, genetically engineered mice lacking functional dopamine D2 receptors have been shown to drink less ethanol in atwo-bottle choice task. To determine whether reduced ethanol intake reflects a reduction in ethanol reward, D2 receptor-deficient [knockout (KO)] mice were compared to heterozygous (HET) and wild-type (WT; C57BL/6 x DBA/2 F2hybrid) mice in a place conditioning task. Under conditions that produced reliable place preference in both WT and HET mice, KO mice showed no evidence of place conditioning, suggesting that D2 receptor gene inactivation reduced ethanol reward or the ability to learn about ethanol reward. Consistent with previous findings, this mutation also produced a gene dose-related reduction in basal activity levels. Moreover, KO and HET mice showed enhancement of ethanol-stimulated activity relative to WT mice. However, differences in basal and ethanol-stimulated activity did not explain the differencesin place conditioning. Overall, this study strongly supports the conclusion that dopamine D2 receptors normally influence ethanol reward in mice. (C)2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 20/01/20 alle ore 07:33:39