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Titolo:
Congenic strains developed for alcohol- and drug-related phenotypes
Autore:
Bennett, B;
Indirizzi:
Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 67, anno: 2000,
pagine: 671 - 681
SICI:
0091-3057(200012)67:4<671:CSDFAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; INBRED MOUSE STRAINS; GENETIC DISSECTION; RECENT PROGRESS; COMPLEX TRAITS; MICE; IDENTIFICATION; ETHANOL; SENSITIVITY; CONSUMPTION;
Keywords:
congenic strain; interval-specific congenic strain; ethanol; alcohol preference; alcohol withdrawal; alcohol sensitivity; pentobarbitol withdrawal; morphine preference; morphine analgesia; QTL mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, B Univ Colorado, Inst Behav Genet, CB 447, Boulder, CO 80309 USA Univ Colorado CB 447 Boulder CO USA 80309 Boulder, CO 80309 USA
Citazione:
B. Bennett, "Congenic strains developed for alcohol- and drug-related phenotypes", PHARM BIO B, 67(4), 2000, pp. 671-681

Abstract

Quantitative trait loci (QTLs) for many alcohol- and drug-related traits have been mapped using well-accepted mapping techniques. The ultimate goal of gene identification necessitates confirmation of the QTL and reduction ofthe interval surrounding the QTL; both can be accomplished in congenic strains. These strains carry a chromosomal region introgressed from a donor strain onto the genetic background of a second, recipient strain. Multiple generations of backcrossing reduce the unlinked donor genome to less than 0.1%. Then, phenotypic comparisons between mice congenic for the donor region and controls from the recipient strain allow confirmation of the QTL effect. Animals with recombinations in the donor region can be used to generate interval-specific congenic recombinant lines. Numerous congenic strains are currently being developed in which chromosomal regions carrying QTLs for alcohol- and drug-related traits have been transferred from one strain onto asecond strain. The purpose of this review is to summarize the chromosomal regions, donor and recipient strains, and results obtained from these congenics. Most researchers developing such strains are willing to share these resources to facilitate localization of the genetic bases of other phenotypes. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:11:42