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Titolo:
The role of endothelins and their receptors in heart failure
Autore:
Giannessi, D; Del Ry, S; Vitale, RL;
Indirizzi:
CNR, Inst Clin Physiol, Lab Cardiovasc Biochem, I-56100 Pisa, Italy CNR Pisa Italy I-56100 siol, Lab Cardiovasc Biochem, I-56100 Pisa, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 2, volume: 43, anno: 2001,
pagine: 111 - 126
SICI:
1043-6618(200102)43:2<111:TROEAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CONVERTING ENZYME-INHIBITION; ACTIVATED PROTEIN-KINASES; ATRIAL-NATRIURETIC-FACTOR; II-INDUCED HYPERTROPHY; A RECEPTOR; SIGNAL-TRANSDUCTION; PLASMA ENDOTHELIN; BIG ENDOTHELIN-1; CARDIAC MYOCYTES;
Keywords:
endothelin; receptors; heart failure; endothelin antagonists; anti-endothelin therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
176
Recensione:
Indirizzi per estratti:
Indirizzo: Giannessi, D CNR, Inst Clin Physiol, Lab Cardiovasc Biochem, Via Savi 8, I-56100 Pisa, Italy CNR Via Savi 8 Pisa Italy I-56100 avi 8, I-56100 Pisa, Italy
Citazione:
D. Giannessi et al., "The role of endothelins and their receptors in heart failure", PHARMAC RES, 43(2), 2001, pp. 111-126

Abstract

Endothelin (ET) is a peptide composed of 21 amino acids, derived from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family; three isoforms of endothelin, named ET-1, ET-2 and ET-3, have been identified. Endothelin-1 is generated mainly by vascular endothelial cells and exerts various important biological actions, mediated by two receptor subtypes, ET-A and ET-B, belonging to the G protein-coupled family that have been identified in various human tissues such as the cardiac tissue. Endothelin-1 is a potent vasoconstrictive agent, has inotropic and mitogenic actions, modulates salt and water homeostasis and plays an important role in the maintenance of vascular tone and blood pressure in healthy subjects. Endothelin-1, as well as ET-A and ECE-1, also has an important role in cardiovascular development, as observed by the variety of abnormalities related to neural crest-derived tissues in mouse embryos deficient of a member of the ET-1/ECE-1/ET-A pathway. Various evidence indicates that endogenous endothelin-1 may contribute to the pathophysiology of conditions associated with sustained vasoconstriction, such as heart failure. In heart failure, elevated circulating levels of both endothelin-1 and big-endothelin-1 are observed; in failing hearts an activation of the endothelin system is found: tissue level of ET-1 is increased with respect to non-failing hearts as well as receptor density, due mainly to an upregulation of the ET-A subtype, the prevalent receptor subclassin cardiac tissue. Finally, studies in both humans and animal models of cardiovascular disease show that inhibition of the endothelin function (anti-endothelin strategy) is associated with an improvement of haemodynamic conditions; these observations indicate that endothelin receptor antagonists or endothelin-converting enzyme inhibitors may constitute a novel and potentially important class of agents for the treatment of this disease. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 04:32:46