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Titolo:
Intrahepatic cholangitis and arteritis after transcatheter arterial embolization in a patient with tumor-like lesion-associated autoimmune hepatitis
Autore:
Iwata, M; Sasaki, M; Harada, K; Kaneko, S; Kobayashi, K; Adachi, K; Sasaki, M; Nakanuma, Y;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Pathol 2, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Kanazawa Natl Hosp, Dept Internal Med, Kanazawa, Ishikawa, Japan Kanazawa Natl Hosp Kanazawa Ishikawa Japan ed, Kanazawa, Ishikawa, Japan Saiseikai Takaoka Hosp, Dept Surg, Takaoka, Toyama, Japan Saiseikai Takaoka Hosp Takaoka Toyama Japan Surg, Takaoka, Toyama, Japan
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 1, volume: 197, anno: 2001,
pagine: 59 - 63
SICI:
0344-0338(2001)197:1<59:ICAAAT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; CHRONIC ACTIVE HEPATITIS; OVERLAP SYNDROME;
Keywords:
autoimmune hepatitis; primary biliary cirrhosis; granulomatous cholangitis; granulomatous arteritis; transcatheter arterial embolization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Nakanuma, Y Kanazawa Univ, Sch Med, Dept Pathol 2, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 9208640, Japan
Citazione:
M. Iwata et al., "Intrahepatic cholangitis and arteritis after transcatheter arterial embolization in a patient with tumor-like lesion-associated autoimmune hepatitis", PATH RES PR, 197(1), 2001, pp. 59-63

Abstract

Autoimmune hepatitis is a chronic liver disease characterized by immune-mediated, progressive hepatocellular damage, although the target autoantigen remains speculative. Intrahepatic biliary lesions are not a feature of thisdisease. We describe herein a female patient, 57 years, with autoimmune hepatitis who developed hepatic regenerative mass after acute exacerbation ofhepatitis. This hepatic regenerative mass was clinically diagnosed as hepatocellular carcinoma and was surgically resected after transcatheter arterial embolization therapy. Widespread nonsuppulative destructive granulomatous cholangitis as well as necrotizing, granulomatous arteritis of the intrahepatic small arteries were found in the surgically resected hepatic regenerative mass. The bile duct lesions were histologically and immunohistochemically very similar to the granulomatous cholangitis of primary biliary cirrhosis. We would like to propose that these unusual lesions in the intrahepatic bile ducts and intrahepatic arteries represent a reaction of this patient to an anti-cancer drug included in chemoembolization. No such cases have been reported so far.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 23:54:37