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Titolo:
A concise enantioselective synthesis of a key A-ring synthon for 1 alpha-hydroxyvitamin D-3 compounds
Autore:
Hiyamizu, H; Ooi, H; Inomoto, Y; Esumi, T; Iwabuchi, Y; Hatakeyama, S;
Indirizzi:
Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 Fac Pharmaceut Sci, Nagasaki 852, Japan
Titolo Testata:
ORGANIC LETTERS
fascicolo: 3, volume: 3, anno: 2001,
pagine: 473 - 475
SICI:
1523-7060(20010208)3:3<473:ACESOA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PD-CATALYZED CYCLIZATION; STEREOSELECTIVE TOTAL SYNTHESIS; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; 25-DIHYDROXYVITAMIN D-3; EFFICIENT ROUTE; ANALOGS; PRECURSORS; 1-ALPHA; SYSTEM; OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hatakeyama, S Nagasaki Univ, Fac Pharmaceut Sci, Bunkyo Machi 1-14, Nagasaki 852, Japan Nagasaki Univ Bunkyo Machi 1-14 Nagasaki Japan 852 2, Japan
Citazione:
H. Hiyamizu et al., "A concise enantioselective synthesis of a key A-ring synthon for 1 alpha-hydroxyvitamin D-3 compounds", ORG LETT, 3(3), 2001, pp. 473-475

Abstract

[GRAPHICS]This report describes a concise enantioselective synthesis of the A-ring synthon for the synthesis of 1 alpha -hydroxyvitamin D-3 compounds, The synthesis involves two notable transformations: (i) stereoselective construction of the enol triflate from the vinyl ketone by Michael addition of Ph2P(O)Li followed by in situ triflation of the resulting enolate and (ii) palladlium catalyzed Heck type cyclization of the enol triflate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:26:26