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Titolo:
Synthesis of cyclic sulfonamides through intramolecular Diels-Alder reactions
Autore:
Greig, IR; Tozer, MJ; Wright, PT;
Indirizzi:
James Black Fdn, London SE24 9JE, England James Black Fdn London EnglandSE24 9JE ck Fdn, London SE24 9JE, England
Titolo Testata:
ORGANIC LETTERS
fascicolo: 3, volume: 3, anno: 2001,
pagine: 369 - 371
SICI:
1523-7060(20010208)3:3<369:SOCSTI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONISTS; HISTAMINE; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Tozer, MJ James Black Fdn, 68 Half Moon Lane, London SE24 9JE, England James Black Fdn 68 Half Moon Lane London England SE24 9JE gland
Citazione:
I.R. Greig et al., "Synthesis of cyclic sulfonamides through intramolecular Diels-Alder reactions", ORG LETT, 3(3), 2001, pp. 369-371

Abstract

[GRAPHICS]Substituted 2,3,3a,4,5,7a-hexahydrobenzo[D]isothiazole 1,1-dioxides and 3,4,4a,5,6,8a-hexahydro-2H-benzo[e][1,2]thiazine 1,1-dioxides, novel cyclic sulfonamides, were synthesized by the thermal Diels-Alder reaction of trienederivatives of buta-1,3-diene 1-sulionic acid amide, The stereochemical outcome of the reaction was determined by NMR spectroscopy and X-ray crystallographic analysis. This chemistry has been used for the synthesis of 2-(4-chlorobenzyl)-5-(1H-imidazol-4-yl)-2,3,3a,4,5,7a-hexahydrobenzo[d]isothiazole 1,1-dioxide, a histamine H-3 receptor antagonist.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 08:43:34