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Titolo:
Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach
Autore:
Meloni, MM; Taddei, M;
Indirizzi:
Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy Univ Sassari Sassari Italy I-07100 rtimento Chim, I-07100 Sassari, Italy
Titolo Testata:
ORGANIC LETTERS
fascicolo: 3, volume: 3, anno: 2001,
pagine: 337 - 340
SICI:
1523-7060(20010208)3:3<337:SSOBVT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACIDS; DERIVATIVES; METHODOLOGY; PEPTIDES; PROTEASE; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Taddei, M Univ Sassari, Dipartimento Chim, Via Vienna 2, I-07100 Sassari, Italy Univ Sassari Via Vienna 2 Sassari Italy I-07100 Sassari, Italy
Citazione:
M.M. Meloni e M. Taddei, "Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach", ORG LETT, 3(3), 2001, pp. 337-340

Abstract

[GRAPHICS]beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:13:49