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Titolo:
Low level Pb2+ exposure affects hippocampal protein kinase C gamma gene and protein expression in rats
Autore:
Nihei, MK; McGlothan, JL; Toscano, CD; Guilarte, TR;
Indirizzi:
Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 th Sci, Baltimore, MD 21205 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 298, anno: 2001,
pagine: 212 - 216
SICI:
0304-3940(20010209)298:3<212:LLPEAH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL LEAD-EXPOSURE; LONG-TERM POTENTIATION; BRAIN; ACTIVATION; TRANSLOCATION; DEFICITS;
Keywords:
protein kinase C gamma; hippocampus; Pb2+; back-phosphorylation; protein kinase C activity; [H-3]phorbol 12,13 dibutyrate binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Guilarte, TR Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, 615 N Wolfe St,Room W2001, Baltimore, MD 21205 USA Johns Hopkins Univ 615 N Wolfe St,Room W2001 Baltimore MD USA 21205
Citazione:
M.K. Nihei et al., "Low level Pb2+ exposure affects hippocampal protein kinase C gamma gene and protein expression in rats", NEUROSCI L, 298(3), 2001, pp. 212-216

Abstract

We examined the effect of chronic exposure to lead (Pb2+) on protein kinase C (PKC) in 50-day-old rat hippocampus. Cytosolic and membrane fractions of hippocampus from Pb2+-exposed rats showed reduced expression of PKC gammaprotein. In contrast, a significant elevation of PKC gamma mRNA was observed in pyramidal and dentate granule cell layers. Protein expression of alpha, betaI, beta II and epsilon isoenzymes were unchanged in Pb2+-exposed rats, as was [H-3]phorbol 12,13 dibutyrate (PDBu) binding in tissue slices. Differences were not observed in Ca2+-dependent or -independent PKC activity,or in PKC-specific back-phosphorylation of hippocampal homogenates from Pb2+-exposed rats. Reduced subcellular levels of PKC gamma in Pb2+-exposed rats suggest that signal transduction in the hippocampus may be selectively altered and may be important in manifesting Pb2+-induced impairments of synaptic plasticity, learning and memory. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 16:28:01