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Titolo:
The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease
Autore:
Russ, C; Lovestone, S; Baker, M; Pickering-Brown, SM; Andersen, PM; Furlong, R; Mann, D; Powell, JF;
Indirizzi:
Inst Psychiat, Dept Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Neurosci, London SE5 8AF, England Inst Psychiat, Old Age Psychiat Sect, London SE5 8AF, England Inst Psychiat London England SE5 8AF chiat Sect, London SE5 8AF, England Mayo Clin Jacksonville, Neurogenet Labs, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA Mayo Clin Jacksonville, Dept Neurol, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA Univ Manchester, Div Neurosci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Umea Hosp, Dept Neurol, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 sp, Dept Neurol, S-90185 Umea, Sweden Umea Univ, Inst Clin Neurosci, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 , Inst Clin Neurosci, S-90185 Umea, Sweden Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England Univ Manchester, Dept Med, Lab Med Acad Grp, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 299, anno: 2001,
pagine: 156 - 158
SICI:
0304-3940(20010216)299:1-2<156:TEHOTM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; FRONTOTEMPORAL DEMENTIA; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; MUTATIONS; ISOFORMS; CHROMOSOME-17; PARKINSONISM; INVOLVEMENT; MISSENSE;
Keywords:
Pick's disease; haplotype; tau; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, JF Inst Psychiat, Dept Neurosci, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF , England
Citazione:
C. Russ et al., "The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease", NEUROSCI L, 299(1-2), 2001, pp. 156-158

Abstract

Pick's disease (PID) is a rare neurodegenerative condition and is a memberof a heterogeneous group of disorders known as tauopathies, so-called because of the predominantly neuronal aberrant tau accumulations found in thesediseases. The tauopathy, familiar frontotemporal dementia (FTD), is causedby mutations in the tau gene. Moreover, progressive supranuclear palsy (PSP) is associated with the tau H1 haplotype. In certain familial forms of FTD and in PSP the microtubule-binding four repeat tau isoform principally accumulates in neuropathological lesions. However, in PID three repeat tau accumulations are found. We therefore investigated whether either the tau H1 or H2 haplotype was associated with PiD. Our results indicate a slight increase in H2H2 frequency in Pick's cases which is not statistically significant. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:24:04