Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients
Autore:
Soares, JC; Dippold, CS; Wells, KF; Frank, E; Kupfer, DJ; Mallinger, AG;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 299, anno: 2001,
pagine: 150 - 152
SICI:
0304-3940(20010216)299:1-2<150:IPMPID>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; AFFECTIVE-DISORDER; SIGNAL-TRANSDUCTION; BLOOD-PLATELETS; SYSTEM;
Keywords:
phosphoinositide; platelet; bipolar disorder; affective disorders; signal transduction; second messenger; pathophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Soares, JC Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
J.C. Soares et al., "Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients", NEUROSCI L, 299(1-2), 2001, pp. 150-152

Abstract

Prior investigations in bipolar disorder patients have suggested abnormalities in the cellular phosphoinositide second messenger system. This study was conducted to examine the levels of platelet membrane phosphoinositides in drug-free bipolar patients in the depressed state (n = 9) and healthy controls (n = 19). Bipolar patients had significantly increased levels of platelet membrane phosphatidylinositol-4,5-bisphosphate (PIP2) compared to healthy individuals (0.67 +/- 0.14 and 0.44 +/- 0.17%, respectively, t-test = 3.71, d.f. = 26, P = 0.001). No significant differences in the levels of phosphatidylinositol-4-phosphate (PIP) (0.65 +/- 0.17 and 0.58 +/- 0.20%, respectively, t-test = 1.02; d.f. = 26; P = 0.32) or phosphatidylinositol (PI) (5.92 +/- 1.23 and 5.56 +/- 1.45%, respectively, t-test = 0.68; d.f. = 26; P = 0.51) were found. These findings provide the first demonstration of increased PIP2 platelet levels in bipolar patients in the depressed state, andprovide additional evidence that the phosphoinositide second messenger system may be a site of abnormality in bipolar disorder. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:22:19