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Titolo:
Prolonged effects of intraventricular galanin on a 5-hydroxytryptamine(1A)receptor mediated function in the rat
Autore:
Razani, H; Diaz-Cabiale, Z; Misane, I; Wang, FH; Fuxe, K; Ogren, SO;
Indirizzi:
Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ci, SE-17177 Stockholm, Sweden Fac Med Malaga, Dept Fisiol, Malaga 29080, Spain Fac Med Malaga Malaga Spain 29080 laga, Dept Fisiol, Malaga 29080, Spain
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 299, anno: 2001,
pagine: 145 - 149
SICI:
0304-3940(20010216)299:1-2<145:PEOIGO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; BRAIN; DORSAL; HYBRIDIZATION; SUBTYPES; NEURONS; 5-HT;
Keywords:
galanin; 5-hydroxytryptamine(1A) receptors; passive avoidance; dorsal hippocampal formation; ventral limbic cortex; receptor autoradiography; in situ hybridization; mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ogren, SO Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 77 Stockholm, Sweden
Citazione:
H. Razani et al., "Prolonged effects of intraventricular galanin on a 5-hydroxytryptamine(1A)receptor mediated function in the rat", NEUROSCI L, 299(1-2), 2001, pp. 145-149

Abstract

Galanin (3 nmol/rat), 2 h after its intracerebroventricular (i.c.v.) administration to male rats, attenuated the passive avoidance (PA) retention deficit induced by the 5-hydroxytryptamine (HT)(1A) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetraline (8-OH-DPAT) (0.2 mg/kg) The reduction in thepostjunctional 5-HT1A receptor-mediated response after i.c.v. galanin was not associated with changes in the mRNA levels and agonist binding properties of cortical limbic 5-HT1A receptors, believed to be the target receptorsmediating the PA deficit caused by 8-OH-DPAT. These results suggest that acute increases of galanin transmission in vivo even after 2 h can counteract limbic 5-HT1A receptor-mediated responses of relevance for affective disorders without significantly affecting gene expression and binding characteristics of cortical limbic 5-HT1A receptors. (C) 2001 Elsevier Science Ireland Ltd. AII rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:59:36