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Titolo:
Effects of fluvoxamine on morphine-induced inhibition of gastrointestinal transit, antinociception and hyperlocomotion in mice
Autore:
Ise, Y; Katayama, S; Hirano, M; Aoki, T; Narita, M; Suzuki, T;
Indirizzi:
Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 xicol, Shinagawa Ku, Tokyo 1428501, Japan Nippon Med Sch Hosp, Sect Pharmaceut Serv, Bunkyo Ku, Tokyo 1138603, JapanNippon Med Sch Hosp Tokyo Japan 1138603 Bunkyo Ku, Tokyo 1138603, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 299, anno: 2001,
pagine: 29 - 32
SICI:
0304-3940(20010216)299:1-2<29:EOFOMI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS ACCUMBENS; MAJOR DEPRESSION; CANCER-PATIENTS; FLUOXETINE; 5-HYDROXYTRYPTAMINE; ANTIDEPRESSANTS; SENSITIZATION; RECEPTORS; PLACEBO; AGONIST;
Keywords:
morphine; fluvoxamine; gastrointestinal transit; antinociceptive effect; locomotor activity; terminal stage of cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, 2-4-41 Ebara,Tokyo 1428501, Japan Hoshi Univ 2-4-41 Ebara Tokyo Japan 1428501 okyo 1428501, Japan
Citazione:
Y. Ise et al., "Effects of fluvoxamine on morphine-induced inhibition of gastrointestinal transit, antinociception and hyperlocomotion in mice", NEUROSCI L, 299(1-2), 2001, pp. 29-32

Abstract

In the present study, the effects of fluvoxamine on the inhibition of gastrointestinal transit, antinociception and hyperlocomotion induced by morphine were investigated in mice. Treatment with morphine (10 mg/kg, subcutaneously (s.c.)) inhibited gastrointestinal transit and hyperlocomotion. These effects were attenuated by fluvoxamine in a dose-dependent manner. On the other hand, morphine (1 mg/kg, s.c.)-induced antinociception was significantly potentiated by fluvoxamine. These results suggest that fluvoxamine combined with morphine may be useful for the treatment of not only depression but also pain in cancer patients without constipation or activation of the mesolimbic dopaminergic system. However, further understanding and clinical studies will be required to confirm this possibility. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:51:06