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Titolo:
Cerebrovascular reactivity following focal brain ischemia in the rat: A functional magnetic resonance imaging study
Autore:
Harris, NG; Lythgoe, MF; Thomas, DL; Williams, SR;
Indirizzi:
Univ Coll London, RCS Unit Biophys, Inst Child Hlth, London, England Univ Coll London London England ophys, Inst Child Hlth, London, England Univ Cambridge, MRC, Ctr Brain Repair, Cambridge, England Univ Cambridge Cambridge England , Ctr Brain Repair, Cambridge, England Univ Manchester, Manchester, Lancs, England Univ Manchester Manchester Lancs England ter, Manchester, Lancs, England
Titolo Testata:
NEUROIMAGE
fascicolo: 2, volume: 13, anno: 2001,
pagine: 339 - 350
SICI:
1053-8119(200102)13:2<339:CRFFBI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CAROTID-ARTERY OCCLUSIONS; DIFFUSION-WEIGHTED MRI; SEVERE HEAD-INJURY; CAT BRAIN; GRADIENT-ECHO; PERFUSION; CONTRAST; TIME; STROKE;
Keywords:
CO2; carbon dioxide; fmri; perfusion; diffusion; stroke; infarction; brain; hypoperfusion; misery perfusion; cerebral ischemia; ADC; apparent diffusion coefficient; reactivity; cerebrovascular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, NG Univ Coll London, RCS Unit Biophys, Inst Child Hlth, Mortimer St, London, England Univ Coll London Mortimer St London England , London, England
Citazione:
N.G. Harris et al., "Cerebrovascular reactivity following focal brain ischemia in the rat: A functional magnetic resonance imaging study", NEUROIMAGE, 13(2), 2001, pp. 339-350

Abstract

An essential goal of stroke research is to identify potentially salvageable regions of brain that may respond to therapy. However, current imaging methods are inadequate for this purpose. We therefore used dynamic magnetic resonance imaging of vascular reactivity following focal occlusion in the rat to determine whether measurement of perfusion reserve would help resolve this problem. We used the increase in blood-oxygen-level-dependent (BOLD) signal that occurs in normal brain following a CO, challenge, to map vascular reactivity over the brain at 30-min intervals for 3.5 h after complete (CO) or partial (PO) focal ischemia, We assessed the regional correspondence between reactivity changes and areas of lowered apparent diffusion coefficient (ADC) and initial perfusion deficit. The area of lowered ADC was significantly smaller in the PO group compared to the CO group despite similar areas of perfusion deficit (P < 0.05), We identified four distinct areas within hypoperfused brain: a core area with low/absent reactivity and low ADC; borderzone areas with normal reactivity and either reduced ADC (CO group) or normal ADC (PO group); and an area with normal ADC and reduced/absent reactivity, In all ischemic regions, the BOLD peak arrival time in the brain was delayed or absent. There was a negative correlation between BOLD peak latency time and ADC (r = -0.42, P < 0.001), although latency alone did not differentiate individual ischemic regions, In conclusion, combining perfusion, ADC, and vascular reactivity mapping of the ischemic brain enables improved discrimination of core and borderzone regions. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:33:15