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Titolo:
Autoradiography of L-type and N-type calcium channels in aged rat hippocampus, entorhinal cortex, and neocortex
Autore:
Kelly, KM; Kume, A; Albin, RL; Macdonald, RL;
Indirizzi:
Allegheny Gen Hosp, Dept Neurol, Pittsburgh, PA 15212 USA Allegheny Gen Hosp Pittsburgh PA USA 15212 urol, Pittsburgh, PA 15212 USA Eli Lilly & Co, Kobe, Hyogo, Japan Eli Lilly & Co Kobe Hyogo JapanEli Lilly & Co, Kobe, Hyogo, Japan Univ Michigan, Dept Neurol, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA Michigan, Dept Neurol, Ann Arbor, MI USA Univ Michigan, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Physiol, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 1, volume: 22, anno: 2001,
pagine: 17 - 23
SICI:
0197-4580(200101/02)22:1<17:AOLANC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-125 OMEGA-CONOTOXIN; CONCENTRATION-DEPENDENT MANNER; BINDING-SITES; PYRAMIDAL NEURONS; ABSENCE EPILEPSY; GERBIL BRAIN; CA1 NEURONS; MODULATION; CURRENTS; LOCALIZATION;
Keywords:
autoradiography; calcium channels; PN200-110; omega-conotoxin GVIA; binding; aging; hippocampus; neocortex; entorhinal cortex; seizures; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, KM Allegheny Gen Hosp, Dept Neurol, 940 S Tower,320 E North Ave, Pittsburgh, PA 15212 USA Allegheny Gen Hosp 940 S Tower,320 E North Ave Pittsburgh PA USA 15212
Citazione:
K.M. Kelly et al., "Autoradiography of L-type and N-type calcium channels in aged rat hippocampus, entorhinal cortex, and neocortex", NEUROBIOL A, 22(1), 2001, pp. 17-23

Abstract

The present study examined blains from 6 17, and 32 month old male (F344X BN)F1 rats to determine whether there was any age-related change in the distribution or density of L-type and N-type Ca2+ channels in hippocampus, entorhinal cortex, and neocortex, areas commonly involved in the generation ofepileptic seizures. The L-type channel antagonist PN200-110 and the N-typechannel antagonist omega -conotoxin GVIA were used to determine specific binding densities and the autoradiographic distribution of ligand binding was quantified by computer-assisted densitometry. One-way ANOVA noted a significant variance in the mean value of binding density between different age groups only in neocortex laminae TV-VI for [H-3]PN200-110 binding (P < 0.05). Post-hoc testings indicated that the mean value of the 17 month old group was significantly less than those of the 6 and 32 month old groups (P ( 0.05). These results indicate no overall age-related change in the number ofL-type and N-type Ca2+ channels in brain areas frequently involved in seizure activity and suggest that age-related changes in brain Ca2+. physiologymay be associated with changes in voltage-gated Ca2+ channel function rather than channel number. (C) 2001 Elsevier Science Inc, All rights reserved.

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Documento generato il 26/11/20 alle ore 19:11:03