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Titolo:
AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice
Autore:
Valastro, B; Ghribi, O; Poirier, J; Krzywkowski, P; Massicotte, G;
Indirizzi:
Univ Quebec, Dept Chim Biol, Trois Rivieres, PQ G9A 5H7, Canada Univ Quebec Trois Rivieres PQ Canada G9A 5H7 Rivieres, PQ G9A 5H7, Canada McGill Ctr Studies Aging, Verdun, PQ H4H 1R3, Canada McGill Ctr Studies Aging Verdun PQ Canada H4H 1R3 dun, PQ H4H 1R3, Canada Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada Univ MontrealMontreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 1, volume: 22, anno: 2001,
pagine: 9 - 15
SICI:
0197-4580(200101/02)22:1<9:ARRALI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; QUISQUALATE RECEPTORS; SYNAPTIC PLASTICITY; SILENT SYNAPSES; MODULATION; INDUCTION; PHOSPHOLIPASE-A2; EXPRESSION; BINDING;
Keywords:
Alzheimer's disease; apolipoprotein E; knockout; plasticity; AMPA receptors; phosphatidylserine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Massicotte, G Univ Quebec, Dept Chim Biol, CP 500, Trois Rivieres, PQ G9A 5H7, Canada Univ Quebec CP 500 Trois Rivieres PQ Canada G9A 5H7 , Canada
Citazione:
B. Valastro et al., "AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice", NEUROBIOL A, 22(1), 2001, pp. 9-15

Abstract

In the present study, modulation of alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors by phosphatidylserine (PS) and synaptic plasticity were investigated in the hippocampus of young (4-month-old) and aged (18-month-old) apolipoprotein E (apoE)-deficient mice. Qualitative as well as quantitative analysis of brain sections in both young and aged apoE-deficient mice did not reveal any substantial changes of AMPA receptor binding in the various hippocampal regions, compared to age-matched controls. Nevertheless, enhancement of AMPA receptor binding elicited by PS treatment was found to be abolished in most hippocampal regions of young apoE-deficient mice, while modulation of AMPA receptors by this phospholipid was not significantly altered in the hippocampal formation of aged apoE-deficient animals. At the electrophysiological level, long-tel-m potentiation (LTP) induced by theta burst stimulation was lower in area. CA1 of the hippocampus ofyoung, but not aged, apoE-deficient mice compared to age-matched controls. These results confirm that apoE is important for AMPA receptor regulation and LTP expression in the hippocampal formation. However, the presence of LTP in aged apoE-deficient animals, together with apparent recovery of the PS action on AMPA receptors, suggests that aged apoE-knockout mice possess compensatory mechanisms that reduce biochemical and electrophysiological alterations of glutamatergic neurons. (C) 2001 Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:54:52