Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Circulating soluble adhesion molecules in ANCA-associated vasculitis
Autore:
Ara, J; Mirapeix, E; Arrizabalaga, P; Rodriguez, R; Ascaso, C; Abellana, R; Font, J; Darnell, A;
Indirizzi:
Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Serv Nephrol, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 Nephrol, E-08036 Barcelona, Spain Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Biostat & Epidemiol Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona SpainE-08036 ol Unit, E-08036 Barcelona, Spain Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Autoimmune Dis Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 is Unit, E-08036 Barcelona, Spain
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 2, volume: 16, anno: 2001,
pagine: 276 - 285
SICI:
0931-0509(200102)16:2<276:CSAMIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; E-SELECTIN; ENDOTHELIAL-CELLS; DISEASE-ACTIVITY; WEGENERS GRANULOMATOSIS; RHEUMATOID-ARTHRITIS; LEUKOCYTE ADHESION; RENAL VASCULITIS; SERUM LEVELS; ICAM-1;
Keywords:
ANCA-associated vasculitis; disease activity; microscopic polyangiitis; soluble adhesion molecules; Wegener's; granulomatosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ara, J Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Serv Nephrol, C Villarroel 170, E-08036 Barcelona, Spain Univ Barcelona C Villarroel 170 Barcelona Spain E-08036 ona, Spain
Citazione:
J. Ara et al., "Circulating soluble adhesion molecules in ANCA-associated vasculitis", NEPH DIAL T, 16(2), 2001, pp. 276-285

Abstract

Background. To evaluate whether changes in concentrations of soluble (s) E-selectin, sP-selectin, sL-selectin, intercellular adhesion molecule I (sICAM-1), and vascular cell adhesion molecule 1 (sVCAM-1) reflect disease activity in patients with ANCA-associated vasculitis and whether serum levels of these adhesion molecules are related to the degree of renal failure in patients with chronic renal failure (CRF). Subjects and methods. A sandwich ELISA was used to measure these soluble adhesion molecules in (ii) sera from 20 patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (10 patients with Wegener's granulomatosis (WG) and 10 patients with microscopic polyangiitis (MPA)), obtained at the time of diagnosis and during the remission period; (ii) sera from 40 patients with CRF not undergoing haemodialysis. Results. At the time of diagnosis, serum levels of sE-selectin, sICAM-1 and sVCAM-1 (88 +/- 42 ng/ml, 437 +/- 184 ng/ml, 1720 +/- 1174 ng/ml respectively) were significantly higher in patients with ANCA-associated vasculitisthan in healthy controls (P < 0.0001, P = 0.002 and P = 0.001 respectively). Serum sP-selectin values did not differ from those obtained in normal donors. In contrast, sl-selectin levels (940 <plus/minus> 349 ng;ml) were significantly lower in patients than those recorded in healthy controls (P < 0.0001). A significant decrease in concentrations of sE-selectin, sP-selectin, sICAM-1, and sVCAM-1 was observed between active and remission phases (P< 0.0001, P = 0.002, P=0.001 and P = 0.001 respectively). No significant differences were observed in sL-selectin levels between active and remissionphases. sl-selectin concentrations (802 +/- 306 ng/ml) during the remission phase remained lower than those observed in healthy controls (P < 0.0001). No correlation was observed between serum creatinine and sE-selectin, sP-selectin, sICAM-1 and sVCAM-1 in patients of the CRF group. A slight negative correlation was established between creatinine and sl-selectin concentration. Conclusions. Increased serum levels of sE-selectin, sICAM-1, and sVCAM-1 and decreased levels of sl-selectin in active ANCA-associated vasculitis, and the normalization of sE-selectin, sICAM-1, and sVCAM-1 during the remission phase suggest that the concentration of soluble levels of these adhesionmolecules reflects disease activity. The decrease in sP-selectin levels between active and inactive phases also suggest that this receptor may reflect clinical activity. The lack of correlation between serum levels of sE-selectin, sP-selectin. sICAM-1, and sVCAM-1 and the degree of renal failure inpatients with CRF Suggests that the mechanism of clearance of these molecules is not renal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 23:53:19