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Titolo:
Vertebrate neural cell-fate determination: Lessons from the retina
Autore:
Livesey, FJ; Cepko, CL;
Indirizzi:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 rd Hughes Med Inst, Boston, MA 02115 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 2, volume: 2, anno: 2001,
pagine: 109 - 118
SICI:
1471-0048(200102)2:2<109:VNCDLF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY ORGAN DEVELOPMENT; DOMAIN FACTOR BRN-3B; OPTX2 HOMEOBOX GENE; CHICK SPINAL-CORD; RAT RETINA; GANGLION-CELLS; XENOPUS RETINA; NEUROFILAMENT PROTEIN; POSTMITOTIC CELLS; PROGENITOR CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Livesey, FJ Harvard Univ, Sch Med, Dept Genet, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
F.J. Livesey e C.L. Cepko, "Vertebrate neural cell-fate determination: Lessons from the retina", NAT REV NEU, 2(2), 2001, pp. 109-118

Abstract

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion during development. Studies of cell-fate determination in the vertebrate retina have uncovered several fundamental principles by whichthis is achieved. Most notably, a model for vertebrate cell-fate determination has been proposed that combines findings on the relative roles of extrinsic and intrinsic regulators in controlling cell-fate choices. At the heart of the model is the proposal that progenitors pass through intrinsicallydetermined competence states, during which they are capable of giving riseto a limited subset of cell types under the influence of extrinsic signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:04:11