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Titolo:
Dancing to the tune of chemokines
Autore:
Thelen, M;
Indirizzi:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland Inst Res Biomed Bellinzona Switzerland CH-6500 0 Bellinzona, Switzerland
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 2, volume: 2, anno: 2001,
pagine: 129 - 134
SICI:
1529-2908(200102)2:2<129:DTTTOC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-B; HUMAN INTERLEUKIN-8 RECEPTOR; BETA-GAMMA-SUBUNITS; SIGNAL-TRANSDUCTION PATHWAYS; HUMAN NEUTROPHIL LEUKOCYTES; PLECKSTRIN HOMOLOGY DOMAIN; COUPLED RECEPTORS; CHEMOATTRACTANT RECEPTORS; PHOSPHOINOSITIDE 3-KINASE; SDF-1-ALPHA TRIGGERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Thelen, M Inst Res Biomed, CH-6500 Bellinzona, Switzerland Inst Res Biomed Bellinzona Switzerland CH-6500 na, Switzerland
Citazione:
M. Thelen, "Dancing to the tune of chemokines", NAT IMMUNOL, 2(2), 2001, pp. 129-134

Abstract

Since their discovery 13 years ago, chemokines have emerged as the most important regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane-domain receptors that are coupled to heterotrimeric G(i) proteins. The common response of all cells to chemokine stimulationis chemotaxis. In addition,leukocyte activation triggers diverse signal transduction cascades; which cascade is triggered depends on the chemokine and receptor engaged. The selective activation of distinct pathways suggests that the receptors couple not only to G proteins but also to additional downstream effecters. This review discusses recent advances in the elucidationof the signal transduction that occurs in proximity to receptors and that leads to the early biochemical events in leukocyte activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:27:09