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Titolo:
Viral exploitation and subversion of the immune system through chemokine mimicry
Autore:
Murphy, PM;
Indirizzi:
NIAID, Host Def Lab, Mol Signaling Sect, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 l Signaling Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 2, volume: 2, anno: 2001,
pagine: 116 - 122
SICI:
1529-2908(200102)2:2<116:VEASOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTOR; IMMUNODEFICIENCY-VIRUS TYPE-1; SARCOMA-ASSOCIATED HERPESVIRUS; HUMAN CYTOMEGALOVIRUS; KAPOSIS-SARCOMA; MURINE CYTOMEGALOVIRUS; HIV-1 INFECTION; BETA-CHEMOKINE; FUNCTIONAL CHEMOKINE; ALPHA-CHEMOKINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, PM NIAID, Host Def Lab, Mol Signaling Sect, NIH, Bldg 10,Room 11N113, Bethesda, MD 20892 USA NIAID Bldg 10,Room 11N113 Bethesda MD USA 20892 a, MD 20892 USA
Citazione:
P.M. Murphy, "Viral exploitation and subversion of the immune system through chemokine mimicry", NAT IMMUNOL, 2(2), 2001, pp. 116-122

Abstract

The chemokine superfamily of leukocyte chemo-attractants coordinates development and deployment of the immune system by signaling through a family ofG protein-coupled receptors. The importance of this system to antimicrobial host defense has been supported by the discovery of numerous herpesviruses and poxviruses that encode chemokine mimics able to block chemokine action. However, specific herpesviruses and lentiviruses can also exploit the immune system through chemokine mimicry, for example, to facilitate viral dissemination or, as in the case of HIV-1, to directly infect leukocyte targetcells. The study of viral mimicry of chemokines and chemokine receptors isproviding important new concepts in viral immunopathogenesis, new anti-inflammatory drug leads and new targets and concepts for antiviral drug and vaccine development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 07:45:54