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Titolo:
Chemokines: immunology's high impact factors
Autore:
Mackay, CR;
Indirizzi:
Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia Garvan Inst Med Res Darlinghurst NSW Australia 2010 , NSW 2010, Australia
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 2, volume: 2, anno: 2001,
pagine: 95 - 101
SICI:
1529-2908(200102)2:2<95:CIHIF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY LYMPHOID ORGANS; DENDRITIC CELL MATURATION; HIGH ENDOTHELIAL VENULES; MEMORY T-CELLS; C-C CHEMOKINE; B-CELL; RECEPTOR CCR3; CUTTING EDGE; AIRWAY HYPERRESPONSIVENESS; SELECTIVE RECRUITMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Mackay, CR Garvan Inst Med Res, 384 Victoria St, Darlinghurst, NSW 2010, Australia Garvan Inst Med Res 384 Victoria St Darlinghurst NSW Australia 2010
Citazione:
C.R. Mackay, "Chemokines: immunology's high impact factors", NAT IMMUNOL, 2(2), 2001, pp. 95-101

Abstract

Chemokines facilitate leukocyte migration and positioning as well as otherprocesses such as angiogenesis and leukocyte degranulation. The burgeoningknowledge on chemokines and their receptors has influenced many aspects ofimmunology, in part because cell migration is; intimately related to leukocyte function. This overview assesses the impact that chemokines have had on our understanding of immunology and infectious diseases. These include the role of chemokines in leukocyte-endothelial cell interactions; dendritic cell function; T cell differentiation and function; inflammatory diseases; mucosal and subcutaneous immunity; and subversion of immune responses by viruses, including HIV-1. This knowledge heralds new opportunities fbr the manipulation of immune responses and the development of new anti-inflammatorytherapies. It has also provided a new perspective on the functioning of the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:03:50