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Titolo:
Localized Igf-1 transgene expression sustains hypertrophy and regenerationin senescent skeletal muscle
Autore:
Musaro, A; McCullagh, K; Paul, A; Houghton, L; Dobrowolny, G; Molinaro, M; Barton, ER; Sweeney, HL; Rosenthal, N;
Indirizzi:
Massachusetts Gen Hosp E, Cardiovasc Res Ctr, Charlestown, MA USA Massachusetts Gen Hosp E Charlestown MA USA Res Ctr, Charlestown, MA USA Univ Rome La Sapienza, Dept Histol & Med Embryol, Rome, Italy Univ Rome LaSapienza Rome Italy Dept Histol & Med Embryol, Rome, Italy Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Physiol, Philadelphia, PA 19104 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 2, volume: 27, anno: 2001,
pagine: 195 - 200
SICI:
1061-4036(200102)27:2<195:LITESH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; DEPENDENT TRANSCRIPTIONAL PATHWAY; CARDIAC-HYPERTROPHY; MICE; DIFFERENTIATION; CALCINEURIN; PROLIFERATION; MYOGENESIS; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenthal, N Massachusetts Gen Hosp E, Cardiovasc Res Ctr, Charlestown, MAUSA Massachusetts Gen Hosp E Charlestown MA USA lestown, MA USA
Citazione:
A. Musaro et al., "Localized Igf-1 transgene expression sustains hypertrophy and regenerationin senescent skeletal muscle", NAT GENET, 27(2), 2001, pp. 195-200

Abstract

Aging skeletal muscles suffer a steady decline in mass and functional performance, and compromised muscle integrity as fibrotic invasions replace contractile tissue, accompanied by a characteristic loss in the fastest, most powerful muscle fibers(1,2). The same programmed deficits in muscle structure and function are found in numerous neurodegenerative syndromes and disease-related cachexia(3). We have generated a model of persistent, functionalmyocyte hypertrophy using a tissue-restricted transgene encoding a locallyacting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mlgf-1), Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-l transgenic models. Expression of CATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic: of younger animals. The preservation of muscle architecture and age-independent regenerative capacity through localized mlgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:09:19