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Titolo:
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
Autore:
Jaffrey, SR; Erdjument-Bromage, H; Ferris, CD; Tempst, P; Snyder, SH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ychiat, Baltimore, MD 21205 USA Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA MemSloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 193 - 197
SICI:
1465-7392(200102)3:2<193:PSAPSF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ACTIVATION; POLYMERASE-II HOLOENZYME; DROSOPHILA DEVELOPMENT; CREATINE-KINASE; SERUM-ALBUMIN; NO; NITROSOGLUTATHIONE; NITROSOTHIOLS; SYNTHASE; GLUTATHIONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Snyder, SH Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 timore, MD 21205 USA
Citazione:
S.R. Jaffrey et al., "Protein S-nitrosylation: a physiological signal for neuronal nitric oxide", NAT CELL BI, 3(2), 2001, pp. 193-197

Abstract

Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events that ave not readily explained by the well established effects of NO on soluble guanylyl cyclase. Exogenous NO S-nitrosylates cysteineresidues in proteins, but whether this is an important function of endogenous NO is unclear. Here, using a new proteomic approach, we identify a population of proteins that are endogenously S-nitrosylated, and demonstrate the loss of this modification in mice harbouring a genomic deletion of neuronal NO synthase (nNOS). Targets of NO include metabolic, structural and signalling proteins that may be effecters for neuronally generated PIG. These findings establish protein S-nitrosylation as a physiological signalling mechanism for nNOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:55:47