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Titolo:
Growth-factor-dependent mitogenesis requires two distinct phases of signalling
Autore:
Jones, SM; Kazlauskas, A;
Indirizzi:
Schepens Eye Res Inst, Boston, MA 02114 USA Schepens Eye Res Inst Boston MA USA 02114 Res Inst, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 d, Dept Ophthalmol, Boston, MA 02115 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 165 - 172
SICI:
1465-7392(200102)3:2<165:GMRTDP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE MACHINERY; RESTRICTION POINT; RAS ACTIVITY; C-MYC; COOPERATING ONCOGENES; INHIBITOR P27(KIP1); EMBRYO FIBROBLASTS; 3T3 CELLS; PROLIFERATION; PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kazlauskas, A Schepens Eye Res Inst, 20 Staniford St, Boston, MA 02114 USASchepens Eye Res Inst 20 Staniford St Boston MA USA 02114 SA
Citazione:
S.M. Jones e A. Kazlauskas, "Growth-factor-dependent mitogenesis requires two distinct phases of signalling", NAT CELL BI, 3(2), 2001, pp. 165-172

Abstract

Prolonged and continuous exposure to growth factors is required to commit cells to the cell cycle. Here we show that the prolonged requirement for growth factor can be replaced with two short pulses of mitogen. The first pulse of growth factor moves the cell through the initial segment of the GO toS interval. This initial pulse also makes cells responsive to a second pulse of growth factor, which engages components of the cell-cycle machinery necessary for progression into S phase. We also show that activation of MAP kinase kinase (MEK) and induction of the transcription factor c-Myc are sufficient to drive the first, but not the second, phase of signalling. Furthermore, synthetic phosphatidylinositol-3-OH kinase (Pi(3)K) lipid products are sufficient to drive the second phase of signalling, but not the first. These findings suggest that there is a common signalling cascade by which mitogens drive arrested cells into the cell cycle, and that this cascade involves the temporally coordinated input of MEK, c-Myc and PI(3)K.

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Documento generato il 10/07/20 alle ore 09:24:20