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Titolo:
Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator
Autore:
Tumbar, T; Belmont, AS;
Indirizzi:
Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 ell & Struct Biol, Urbana, IL 61801 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 134 - 139
SICI:
1465-7392(200102)3:2<134:IMOADC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE; 3-DIMENSIONAL RECONSTRUCTION; CENTROMERIC HETEROCHROMATIN; NUCLEAR-ORGANIZATION; X-CHROMOSOME; IN-VIVO; CHROMATIN; DOMAINS; TERRITORIES; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Belmont, AS Univ Illinois, Dept Cell & Struct Biol, Room B107 C&LSL,601 S Goodwin Ave,Urbana, IL 61801 USA Univ Illinois Room B107 C&LSL,601 S Goodwin Ave Urbana IL USA 61801
Citazione:
T. Tumbar e A.S. Belmont, "Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator", NAT CELL BI, 3(2), 2001, pp. 134-139

Abstract

We examined changes in intranuclear chromosome positioning induced by a transcriptional activator in a simple experimental system. Targeting the VP16acidic activation domain (AAD) to an engineered chromosome site resulted in its transcriptional activation and redistribution from a predominantly peripheral to a more interior nuclear localization. Direct visualization in vivo revealed that the chromosome site normally moves into the nuclear interior transiently in early G1 and again in early S phase. In contrast, VP16 AAD targeting induced this site's permanent interior localization in early G1. A single transcriptional activator therefore can modify the cell-cycle-dependent programme of intranuclear positioning of chromosome loci.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:02:20