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Titolo:
Computational comparison of two draft sequences of the human genome
Autore:
Aach, J; Bulyk, ML; Church, GM; Comander, J; Derti, A; Shendure, J;
Indirizzi:
Harvard Univ, Sch Med, Lipper Ctr Computat Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Ctr Computat Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Program Biophys, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 d, Program Biophys, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Boston Univ, Program Bioinformat, Boston, MA 02215 USA Boston Univ BostonMA USA 02215 Program Bioinformat, Boston, MA 02215 USA
Titolo Testata:
NATURE
fascicolo: 6822, volume: 409, anno: 2001,
pagine: 856 - 859
SICI:
0028-0836(20010215)409:6822<856:CCOTDS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; GROWTH; TOOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Church, GM Harvard Univ, Sch Med, Lipper Ctr Computat Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 t Genet, Boston, MA 02115 USA
Citazione:
J. Aach et al., "Computational comparison of two draft sequences of the human genome", NATURE, 409(6822), 2001, pp. 856-859

Abstract

We are in the enviable position of having two distinct drafts of the humangenome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. We look at a number of features of the sequences, including sequence gaps, continuity, consistency between the two sequences and patterns of DNA-binding protein motifs.

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Documento generato il 25/11/20 alle ore 15:53:03