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Titolo:
Telomeric associations in cigarette smokers exposed to low levels of X-rays
Autore:
Paz-y-Mino, C; Perez, JC; Davalos, V; Sanchez, ME; Leone, PE;
Indirizzi:
Pontificia Univ Catolica Ecuador, Dept Ciencias Biol, Lab Genet Mol & Citogenet Humana, Quito, Ecuador Pontificia Univ Catolica Ecuador Quito Ecuador t Humana, Quito, Ecuador Pontificia Univ Catolica Ecuador, Fac Med, Quito, Ecuador Pontificia Univ Catolica Ecuador Quito Ecuador Fac Med, Quito, Ecuador
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1, volume: 490, anno: 2001,
pagine: 77 - 80
SICI:
1383-5718(20010125)490:1<77:TAICSE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CANCER; CHROMOSOME-ABERRATIONS; PERIPHERAL LYMPHOCYTES; INSTABILITY; FUSIONS; CELLS;
Keywords:
telomeric associations; cigarette smoking; x-rays; synergistic effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Paz-y-Mino, C Pontificia Univ Catolica Ecuador, Dept Ciencias Biol, Lab Genet Mol & Citogenet Humana, POB 17-1-2184, Quito, Ecuador Pontificia Univ Catolica Ecuador POB 17-1-2184 Quito Ecuador
Citazione:
C. Paz-y-Mino et al., "Telomeric associations in cigarette smokers exposed to low levels of X-rays", MUT RES-GTE, 490(1), 2001, pp. 77-80

Abstract

Telomeric association (TA), i.e. fusion of chromosomes by their telomeres,predisposes a cell to genetic instability. Because of this we investigatedthe effect of X-rays exposure and cigarette smoking on the frequency of TAin peripheral blood lymphocytes of exposed individuals, in order to determine if TA can be a chromosomal marker in populations exposed to these carcinogens and if there is an synergistic effect between both agents. We found that the exposed groups show a greater percentage of TA when compared with the control group (P < 0.001). However, although the percentage of metaphases with TA in the group with combined exposure (12.6%) was greater than in the others exposed groups (P < 0.05), this value was less than the sum of the two individual effects (15.1%). Our results suggest that probably there is not an additive or synergistic effect between X-rays and smoking, and that TA may be a useful cytogenetic marker for evaluating populations exposedto mutagens. (C) 2001 published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:52:43