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Titolo:
Prevalence of homozygous deletions of the parkin gene in a cohort of patients with sporadic and familial Parkinson's disease
Autore:
Ujike, H; Yamamoto, M; Kanzaki, A; Okumura, K; Takaki, M; Kuroda, S;
Indirizzi:
Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Neuropsychiat, Okayama 7008558, Japan Kagawa Cent Hosp, Dept Neurol, Kagawa, Japan Kagawa Cent Hosp Kagawa Japan awa Cent Hosp, Dept Neurol, Kagawa, Japan Tottori City Hosp, Dept Neurol, Tottori, Japan Tottori City Hosp TottoriJapan City Hosp, Dept Neurol, Tottori, Japan Onomichi City Hosp, Dept Neurol, Omomichi, Japan Onomichi City Hosp Omomichi Japan ty Hosp, Dept Neurol, Omomichi, Japan Midori Hosp, Dept Neuropsychiat, Midori, Japan Midori Hosp Midori JapanMidori Hosp, Dept Neuropsychiat, Midori, Japan
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 1, volume: 16, anno: 2001,
pagine: 111 - 113
SICI:
0885-3185(200101)16:1<111:POHDOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; MUTATIONS;
Keywords:
prevalence; cohort study; AR-JP; parkin gene; homozygous deletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ujike, H Okayama Univ, Sch Med, Dept Neuropsychiat, 2-5-1 Shikata-cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata-cho Okayama Japan 7008558 8558, Japan
Citazione:
H. Ujike et al., "Prevalence of homozygous deletions of the parkin gene in a cohort of patients with sporadic and familial Parkinson's disease", MOVEMENT D, 16(1), 2001, pp. 111-113

Abstract

Mutation of the parkin gene is a cause of familial Parkinson's disease of the autosomal recessive form; however, its significance in all Parkinson's disease cases is unclear. Deletions in the parkin gene were found in only 2.2% of 184 Japanese patients with Parkinsons disease. However, deletions were present in 25.0% and 40.0% of the patients with juvenile-onset (< 40 y) and with familiality, respectively. On the other hand, deletions were not found in any adult-onset cases (> 40 y). Half of the patients with parkin gene-related Parkinson's disease lacked both heredity and consanguinity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:03:44