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Titolo:
The auditory startle reaction in parkinsonian disorders
Autore:
Kofler, M; Muller, J; Wenning, GK; Reggiani, L; Hollosi, P; Bosch, S; Ransmayr, G; Valls-Sole, J; Poewe, W;
Indirizzi:
Hosp Hochzirl, Dept Neurol, A-6170 Zirl, Austria Hosp Hochzirl Zirl Austria A-6170 irl, Dept Neurol, A-6170 Zirl, Austria Univ Innsbruck Hosp, Dept Neurol, A-6020 Innsbruck, Austria Univ InnsbruckHosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Hosp Clin, Neurol Serv, Barcelona, Spain Hosp Clin Barcelona SpainHosp Clin, Neurol Serv, Barcelona, Spain
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 1, volume: 16, anno: 2001,
pagine: 62 - 71
SICI:
0885-3185(200101)16:1<62:TASRIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SYSTEM ATROPHY; PROGRESSIVE SUPRANUCLEAR PALSY; RICHARDSON-OLSZEWSKI-SYNDROME; CLINICAL-DIAGNOSIS; INTERNATIONAL WORKSHOP; LEWY BODY; DISEASE; REFLEX; ACCURACY; HABITUATION;
Keywords:
auditory startle reaction; dementia with Lewy bodies; Parkinson's disease; multiple-system atrophy; progressive supranuclear palsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kofler, M Hosp Hochzirl, Dept Neurol, Anna-Dengel-Haus, A-6170 Zirl, Austria Hosp Hochzirl Anna-Dengel-Haus Zirl Austria A-6170 irl, Austria
Citazione:
M. Kofler et al., "The auditory startle reaction in parkinsonian disorders", MOVEMENT D, 16(1), 2001, pp. 62-71

Abstract

The auditory startle reaction to an unexpected loud stimulus is regarded as a brainstem reflex originating in the nucleus reticularis pontis caudalisand being distributed up the brainstem and down the spinal cord along slowly conducting pathways. Auditory startle responses (ASR) have been reportedabsent or reduced in progressive supranuclear palsy (PSP), and delayed in Parkinson's disease (PD), but normal in multiple-system atrophy (MSA). For the first time we studied ASR in patients fulfilling the clinical criteria of dementia with Lewy bodies (DLB) (n = 8), a neurodegenerative disorder characterized by cortical and subcortical depositions of Lewy bodies resulting in parkinsonism and progressive cognitive decline. For comparison, we also investigated patients with PD (n = 10), MSA (n = 7), PSP (n = 10), and age-matched healthy controls(n = 10). ASR were elicited by binaural high-intensity auditory stimuli. Surface electromyographic activity was simultaneously recorded from facial. upper, and lower extremity muscles. For each muscle, we assessed response probability and measured latency, amplitude, duration, and habituation rate. Patients with DLB had fewer and abnormally delayed ASR of low amplitude and short duration in extremity muscles compared to healthy controls. Furthermore, we confirm and extend previous findings of abnormal ASR in PSP and PD, and also demonstrate exaggerated ASR in extremity muscles of MSA patients. The different patterns of ASR abnormalities may reflect distinct types of brainstem dysfunction in DLB, PD. MSA, and PSP.

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Documento generato il 26/01/20 alle ore 00:49:45