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Titolo:
Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients
Autore:
Abul, H; Abul, A; Khan, I; Matthew, TC; Ayed, A; Al-Athary, E;
Indirizzi:
Kuwait Univ, Hlth Sci Ctr, Fac Med, Dept Pharmacol, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 Med, Dept Pharmacol, Safat 13110, Kuwait Kuwait Univ, Hlth Sci Ctr, Fac Med, Dept Biochem, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 ac Med, Dept Biochem, Safat 13110, Kuwait Kuwait Univ, Hlth Sci Ctr, Fac Med, Dept Surg, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 , Fac Med, Dept Surg, Safat 13110, Kuwait Kuwait Univ, Hlth Sci Ctr, Fac Allied Hlth Sci & Nursing, Dept Med Lab Sci, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 ng, Dept Med Lab Sci, Safat 13110, Kuwait
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 217, anno: 2001,
pagine: 107 - 112
SICI:
0300-8177(200101)217:1-2<107:LOIAMI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; BRONCHOALVEOLAR LAVAGE FLUID; LYSOSOMAL ENZYME RELEASE; INTERLEUKIN-8 IL-8; BACTERIAL PNEUMONIA; CHEMOTACTIC FACTORS; HUMAN LEUKOCYTES; IN-VITRO; NEUTROPHILS; ASTHMA;
Keywords:
interleukin-8; bronchioalveolar lavage; polymerase chain reaction; IL-8 mRNA; myeloperoxidase; pneumonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Abul, H Kuwait Univ, Hlth Sci Ctr, Fac Med, Dept Pharmacol, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 923, Safat 13110, Kuwait
Citazione:
H. Abul et al., "Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients", MOL C BIOCH, 217(1-2), 2001, pp. 107-112

Abstract

Interleukin-8 (IL-8) is considered as the major polymorphonuclear neutrophils (PMNs) chemoattractant cytokine in lung diseases such as asthma and adult respiratory distress syndrome (ARDS). However, controversial results were obtained regarding the involvement of IL-8 in the pathogenesis of pneumonia. This study examines the role of IL-8 in the recruitment and activation of PMNs in the lung of pneumonia patients. The interesting aspect of this study is that it is a site- specific analysis of the infected and uninfectedlungs of the same patient. The level of IL-8 mRNA, protein and myeloperoxidase present in the cells of the bronchioalveolar lavages (BALs) taken fromthe areas of known pneumonic consolidations on chest X-ray (infected lung)are compared with the BALs obtained from areas of no obvious infiltrate (non-infected lung). The results obtained from the infected and non-infected lungs of pneumonic patients were further compared with that of a control group of non-smoking patients. The level of IL-8 mRNA and protein were determined by RT-PCR and ELISA respectively. There was a significant increase in the level of IL-8 mRNA in the infected lung as compared to its level in thenon-infected lung (p < 0.001). In correlation with the increase in mRNA, IL-8 protein concentrations in BAL fluids from the infected lung were 6 foldhigher than those taken from the non-infected lung (p < 0.0001). This pattern was also consistent with MPO activity in the BALs (4.5 fold more MPO activity in the infected lung as compared to that of the non-infected lung), indicating that IL-8 is directly implicated in neutrophil accumulation thatfollows acute respiratory infection. The results of the present study, therefore, indicate the involvement of IL-8 in the pathogenesis of pneumonia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:20:15